发明授权
- 专利标题： HUMAN JTV1 GENE OVERLAPS PMS2 GENE
- 专利标题（中）： 人类JTV1基因重叠PMS2基因
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申请号： EP96930577.0申请日： 1996-08-26
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公开(公告)号： EP0852620B1公开(公告)日： 2003-10-22
- 发明人: VOGELSTEIN, Bert , KINZLER, Kenneth W. , NICOLAIDES, Nicholas C.
- 申请人： THE JOHNS HOPKINS UNIVERSITY
- 申请人地址： 720 Rutland Avenue Baltimore, MD 21205-2109 US
- 专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： 720 Rutland Avenue Baltimore, MD 21205-2109 US
- 代理机构： Dean, John Paul
- 优先权： US518862 19950824
- 国际公布： WO97008312 19970306
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C07K14/47 ; C12N1/21 ; C12Q1/68
摘要：
The hPMS2 gene encodes a protein which is involved in DNA mismatch repair and is mutated in a subset of patients with hereditary nonpolyposis colon cancer (HNPCC). The previously published hPMS2 cDNA sequence lacks an upstream in-frame stop codon preceding the presumptive initiating methionine. To further evaluate the 5' terminus of the hPMS2 coding region, we isolated additional cDNA clones, RT-PCR products, and the corresponding 5' genomic segment of the hPMS2 locus. The hPMS2 gene transcripts were found to have heterogeneous but collinear 5' termini, one of which contained an in-frame termination codon preceding the initiating methionine. In addition, a gene encoding a 34.5 kDa polypeptide was found to transcriptionally initiate within hPMS2 from the opposite strand.
公开/授权文献
- EP0852620A1 HUMAN JTV1 GENE OVERLAPS PMS2 GENE 公开/授权日：1998-07-15
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