公开(公告)号：EP4458368A1

公开(公告)日：2024-11-06

申请号：EP22914852.3

申请日：2022-12-28

申请人： Beijing Yitubaihui Biotech Co., Ltd

发明人： SUN, Chenglong ,  WEI, Dongdong ,  YU, Qian ,  WANG, Yi ,  HE, Gaiying ,  CUI, Junsheng ,  LI, Xiaoran

IPC分类号： A61K38/17 ,  C07K14/47 ,  C12N15/12 ,  C12N15/70 ,  A61P17/14 ,  A61P17/10

摘要： Provided are a use of recombinant calreticulin in hair growth, hair breeding, hair protection or anti-hair loss and a related product. The recombinant protein is derived from the full length of calreticulin or a fragment thereof, and has the functions of treating hair loss and improving hair by means of injection or application. Therefore, calreticulin is expected to be developed into an effective method and means for treating hair loss and improving hair.

公开(公告)号：EP4457336A2

公开(公告)日：2024-11-06

申请号：EP22917608.6

申请日：2022-12-30

申请人： Empyrean Neuroscience, Inc.

发明人： HENLEY, Thomas ,  CHOUDHRY, Modassir ,  FERNANDEZ-GOMEZ, Jose ,  LARRIEU, Antoine ,  ORMAN-LIGEZA, Beata ,  MOHAMMED, Umar ,  MCKECHNIE-WELSH, Emma

IPC分类号： C12N1/14 ,  A23L31/00 ,  A61K36/07 ,  A61P25/24 ,  C12N9/10 ,  C12N15/12 ,  C12N9/22 ,  C12N15/113 ,  C12N15/80 ,  C12Q1/48 ,  G01N33/52

公开(公告)号：EP4446343A1

公开(公告)日：2024-10-16

申请号：EP22904212.2

申请日：2022-12-06

申请人： OSAKA UNIVERSITY ,  Periotherapia Co., Ltd.

发明人： TANIYAMA, Yoshiaki ,  SANADA, Fumihiro ,  MORISHITA, Ryuichi

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P9/14 ,  A61P29/00 ,  A61P35/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/13

摘要： An object is to provide a novel antibody or antigen-binding fragment thereof against exon 21 of human periostin. The object is achieved by an antibody or antigen-binding fragment thereof bindable to a conformational epitope on human periostin, wherein the epitope contains the amino acid sequence A represented by SEQ ID NO: 61 and the amino acid sequence B represented by any one of SEQ ID NOs: 62 to 64.

公开(公告)号：EP3872087B1

公开(公告)日：2024-09-25

申请号：EP19877316.0

申请日：2019-10-25

IPC分类号： C07K14/705 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/705 ,  C12N15/85 ,  C12N2510/0020130101 ,  C12N2501/230420130101 ,  C12N2501/231520130101 ,  C12N2501/230720130101 ,  C12N2501/2220130101 ,  C12N5/0636 ,  C07K14/7051 ,  C07K14/5406 ,  C07K14/535 ,  C12N2800/9020130101 ,  A61K48/00 ,  A61K39/464402 ,  A61K39/4611 ,  A61K2239/1720230501 ,  A61K39/4631

公开(公告)号：EP3512938B1

公开(公告)日：2024-08-28

申请号：EP17849960.4

申请日：2017-09-13

IPC分类号： C12N5/10 ,  C07K14/705 ,  C12N15/12 ,  C12N15/85 ,  C12N15/86 ,  C12N5/077 ,  C12N7/01 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/50

CPC分类号： C07K14/705 ,  G01N33/5061 ,  C12N2740/1604320130101 ,  C12N5/0657 ,  C12N2503/0220130101 ,  C12N2510/0020130101

公开(公告)号：EP4417684A1

公开(公告)日：2024-08-21

申请号：EP22881009.9

申请日：2022-10-11

申请人： AJINOMOTO CO., INC.

发明人： USAMI Riku ,  TOYAZAKI Miku ,  NAKAMURA Hidehiro ,  MATSUDA Yoshihiko

IPC分类号： C12N1/21 ,  A61K35/74 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P9/10 ,  A61P17/00 ,  A61P17/02 ,  A61P35/00 ,  C12N15/12 ,  C12P1/04 ,  C12P21/02

CPC分类号： A61K35/74 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P9/10 ,  A61P17/00 ,  A61P17/02 ,  A61P35/00 ,  C07K14/435 ,  C12N15/74 ,  C12P1/04 ,  C12P21/02

摘要： Provided is a technology whereby a heterologous protein can be expressed in a bacterium which does not have an endogenous Tat system secretion machine. The present specification discloses a bacterium that is selected from the group consisting of bifidobacteria, lactococci, and staphylococci and has been modified to express a heterologous Tat protein. The bacterium has the ability to produce and secrete a heterologous protein.

公开(公告)号：EP4410980A1

公开(公告)日：2024-08-07

申请号：EP22876367.8

申请日：2022-09-28

申请人： Takeda Pharmaceutical Company Limited

发明人： YAMAMOTO, Shunsuke ,  NAKAYAMA, Miyu ,  HIRABAYASHI, Hideki

IPC分类号： C12N15/12 ,  C12Q1/686

CPC分类号： C12Q1/686 ,  C07K14/435

摘要： Disclosed is a method for measuring a cell concentration in a sample, the method including the following steps of: (1) measuring the number of copies of a specific gene and a gene of an external standard in a plurality of standard samples each having a known cell concentration by using digital PCR (dPCR); (2) normalizing the measured value of the specific gene measured in the step (1) using the measured value of the external standard and creating a calibration curve on the basis of the normalized value and the known cell concentration; (3) measuring the number of copies of the same specific gene and gene of the external standard in a sample having an unknown cell concentration by using dPCR; and (4) normalizing the measured value of the specific gene measured in the step (3) using the measured value of the external standard and determining a cell concentration using the calibration curve created in the step (2) from the normalized value.

公开(公告)号：EP4402159A1

公开(公告)日：2024-07-24

申请号：EP22868501.2

申请日：2022-09-16

申请人： Université de Montréal

发明人： PERREAULT, Claude ,  THIBAULT, Pierre ,  CLEYLE, Jenna ,  HARDY, Marie-pierre

IPC分类号： C07K14/705 ,  A61K38/20 ,  A61K39/00 ,  A61P35/00 ,  C07K7/06 ,  C07K14/00 ,  C12N5/07 ,  C12N5/078 ,  C12N5/0783 ,  C12N5/0784 ,  C12N15/12 ,  C12Q1/6809 ,  G01N33/48 ,  G01N33/68

CPC分类号： A61P35/00 ,  C07K14/7051 ,  C07K14/4748 ,  A61K39/0011 ,  A61K39/00 ,  A61K2039/8220180801 ,  C07K16/30 ,  A61K45/06

公开(公告)号：EP4382607A1

公开(公告)日：2024-06-12

申请号：EP22853205.7

申请日：2022-08-05

申请人： Kao Corporation

发明人： SAYAMA, Keimon ,  SUGANUMA,Takaya ,  HORI, Satoshi ,  KUBO, Shun ,  YAMAMOTO, Masaki ,  FUKAGAWA, Satoko ,  ISHIKAWA, Junko

IPC分类号： C12N15/12 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/12 ,  A61K39/35 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P35/00 ,  A61P37/04 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/47 ,  C12N15/63

CPC分类号： Y02A50/30 ,  A61K31/7088 ,  A61K35/76 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00 ,  C07K14/435 ,  C12N15/62 ,  C12N15/85 ,  A61K39/02 ,  A61K39/35 ,  A61P37/08 ,  A61K39/12 ,  A61K39/002 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P37/06 ,  C07K14/47 ,  C12N15/63

摘要： Provided is a nucleic acid structure which enhances an allergen-specific immune response. The nucleic acid structure comprises a polynucleotide encoding a SNARE protein and a polynucleotide encoding an allergen.

公开(公告)号：EP4382605A1

公开(公告)日：2024-06-12

申请号：EP22853203.2

申请日：2022-08-05

申请人： Kao Corporation

发明人： SAYAMA, Keimon ,  SUGANUMA,Takaya ,  HORI, Satoshi ,  KUBO, Shun ,  YAMAMOTO, Masaki ,  FUKAGAWA, Satoko ,  ISHIKAWA, Junko

IPC分类号： C12N15/12 ,  A61K39/00 ,  A61K39/002 ,  A61K39/02 ,  A61K39/12 ,  A61K39/35 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P35/00 ,  A61P37/04 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/47 ,  C12N15/63

CPC分类号： Y02A50/30 ,  A61K31/7088 ,  A61K35/76 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00 ,  C07K14/435 ,  C12N15/62 ,  C12N15/85 ,  A61K39/02 ,  A61K39/35 ,  A61P37/08 ,  A61K39/12 ,  A61K39/002 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P37/06 ,  C07K14/47 ,  C12N15/63

摘要： Provided is a nucleic acid structure which enhances an antigen-specific immune response. The nucleic acid structure comprises a polynucleotide encoding a SNARE protein selected from the group consisting of VAMP7, GOSR2, STX10, STX18, BNIP1, STX7, VTI1A, STX16, STX5, GOSR1, STX8, STX12, VAMP8 and SEC22B, and a polynucleotide encoding an antigen.