发明公开
- 专利标题： CELL DEATH PROTEIN
- 专利标题（中）： ZELLTOD蛋白
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申请号： EP96911803申请日： 1996-04-18
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公开(公告)号： EP0852627A4公开(公告)日： 2002-04-17
- 发明人: LEDER PHILIP , SEED BRIAN , STRANGER BEN Z , LEE TAE-HO , KIM EMILY
- 申请人： HARVARD COLLEGE , GEN HOSPITAL CORP
- 专利权人： HARVARD COLLEGE,GEN HOSPITAL CORP
- 当前专利权人： HARVARD COLLEGE,GEN HOSPITAL CORP
- 优先权： US44400595 1995-05-18
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; A61K38/00 ; A61K48/00 ; C07K14/46 ; C07K14/715 ; C07K16/18 ; C07K16/24 ; C12N5/10 ; C12N9/12 ; C12N15/09 ; C12P21/02 ; C12P21/04 ; C12P21/08 ; C12Q1/02 ; C12R1/91 ; G01N33/15 ; G01N33/577 ; C12Q1/68 ; A01N43/04 ; C07H21/04 ; C07K1/00 ; C07K16/00 ; C12N5/00 ; C12P21/06 ; G01N33/53
摘要：
Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.
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