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公开(公告)号：EP4499665A2
公开(公告)日：2025-02-05
申请号：EP23716649.1
申请日：2023-03-24
Applicant: Pelgen Limited
Inventor： TRIM, Steven , MCCULLOUGH, Danielle
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2.发明授权
公开(公告)号：EP3934614B1
公开(公告)日：2024-11-27
申请号：EP20709166.1
申请日：2020-03-04
Inventor： RASTRELLI, Gianbattista , RASTRELLI, Francesco
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公开(公告)号：EP4423111A1
公开(公告)日：2024-09-04
申请号：EP23704184.3
申请日：2023-02-15
Applicant: Lipotrue, S.L.
Inventor： GRAU-CAMPISTANY, Ariadna , PASTOR, Silvia , CARULLA, Patricia , ESCUDERO, Juan Carlos , KLEIN, Marco Jan , TRIM, Steven Anthony
CPC classification number: A61K8/64 , C07K7/06 , C07K14/461 , A61Q19/08
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公开(公告)号：EP4338756A3
公开(公告)日：2024-06-05
申请号：EP23216609.0
申请日：2016-08-19
Applicant: Autolus Limited
Inventor： PULÉ, Martin , CORDOBA, Shaun , RIGHI, Matteo , SILLIBOURNE, James , ONUOHA, Shimobi , THOMAS, Simon
CPC classification number: C07K14/46 , A61K2039/5552220130101 , A61P35/00 , A61K39/001182 , A61K39/001194 , A61K39/001116 , A61K39/001135 , C12N5/0636 , A61K39/4631 , A61K39/464495 , A61K39/464494 , A61K39/4611
Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising:
(i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and
(ii) a cytokine receptor endodomain.-
公开(公告)号：EP3097114B1
公开(公告)日：2024-04-10
申请号：EP15701169.3
申请日：2015-01-21
Inventor： SÖLLNER, Christian , GAO, Xuefan , NÜSSLEIN-VOLHARD, Christiane
IPC: A61K38/00 , C07K14/475 , C07K14/47 , C07K14/46
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Patent Agency Ranking6.发明公开
公开(公告)号：EP4303227A1
公开(公告)日：2024-01-10
申请号：EP22763449.0
申请日：2022-03-07
Applicant: AJINOMOTO CO., INC.
Inventor： NAKAHARA, Yuichi , ENDO, Yuta , INOUE, Ippei , OKASORA, Takahiro , HOSHIDA YAMAZAKI, Junko , KARAKAWA, Sachise
IPC: C07K14/46 , A61K31/7088 , A61K38/02 , C12N15/113
Abstract: the present invention provides a method for producing a protein having a supramolecular structure in which a bioactive substance is encapsulated, comprising: (I) bringing a subunit of a protein, which forms a supramolecular structure, a bioactive substance, and a solution for forming the protein having the supramolecular structure from the subunit into contact with one another in a flow micro mixer.
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7.发明授权
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公开(公告)号：EP4061955A1
公开(公告)日：2022-09-28
申请号：EP20808266.9
申请日：2020-11-19
Applicant: The Regents of the University of California
Inventor： LEWIS, Nathan, E. , CHIANG, Wan-Tien , LIANG, Chenguang
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公开(公告)号：EP4008337A1
公开(公告)日：2022-06-08
申请号：EP20839663.0
申请日：2020-07-09
Applicant: Qi, Zhankai
Inventor： QI, Hyatt , QI, Zhankai
Abstract: Opioid induced tolerance and hyperalgesia are two closely related yet different symptoms. The former analgesic tolerance refers to the decline in analgesic effects of an opioid, whilst the latter refers to the patient's abnormal pain response to non-injurious stimuli or a highly sensitive pain response to the same injurious stimuli caused by continuous applications of opioid receptor agonists. Analgesic tolerance and hyperalgesia, although two different adverse reactions induced by opioid receptor agonists, both impede the long-term clinical use of opioids. Consequently, patients under the long-term prescription of such drugs are left to face severe side effects, thus a major unmet clinical need.
Elapidae neurotoxin, not only it inhibits opioid induced hyperalgesia and tolerance, but also it can produce synergistic analgesic effect with an opioid for the treatment of pain, hence it decreases the severe side effect of opioid such as morphine, and synergizes the anti-nociceptive effect of opioid.-
公开(公告)号：EP3993765A1
公开(公告)日：2022-05-11
申请号：EP20836324.2
申请日：2020-07-06
Applicant: Regenics AS
Inventor： ROBERTSON, Adam , LUND, Henrik
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