发明公开
- 专利标题： Purification process of keto acids
- 专利标题（中）： Verfahren zur Reinigung vonKetosäuren
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申请号： EP97309175.4申请日： 1997-11-14
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公开(公告)号： EP0853078A1公开(公告)日： 1998-07-15
- 发明人: Taylor, James Philip , Henshall, John Barry , Whitworth, John
- 申请人： Ciba Specialty Chemicals Holding Inc.
- 申请人地址： Klybeckstrasse 141 4057 Basel CH
- 专利权人： Ciba Specialty Chemicals Holding Inc.
- 当前专利权人： Ciba Specialty Chemicals Holding Inc.
- 当前专利权人地址： Klybeckstrasse 141 4057 Basel CH
- 优先权： GB9700375 19970109
- 主分类号： C07C227/38
- IPC分类号： C07C227/38 ; C07C227/42 ; C07C229/52
摘要：
A method for the purification of a keto acid having the general formula
wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl both of which may be substituted by at least one substituent selected from the group consisting of halogen atoms and alkyls having 1-4 carbon atoms, an aralkyl of 7-10 carbon atoms, alkoxyalkyl having 2-20 carbon atoms, tetrahydrofuryl alkyl, alkylcarboxy alkyl, alkyl carboxy benzyl, or R1 and R2 together with the adjacent nitrogen atom may form a heterocyclic ring, or one of R 1 and R 2 is hydrogen, which comprises slurrying the keto acid with an alcohol solvent, maintaining the slurry at elevated temperature in a sealed vessel until the Rhodamine impurity has dissolved, cooling and isolating the pure keto acid by filtration.
wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl both of which may be substituted by at least one substituent selected from the group consisting of halogen atoms and alkyls having 1-4 carbon atoms, an aralkyl of 7-10 carbon atoms, alkoxyalkyl having 2-20 carbon atoms, tetrahydrofuryl alkyl, alkylcarboxy alkyl, alkyl carboxy benzyl, or R1 and R2 together with the adjacent nitrogen atom may form a heterocyclic ring, or one of R 1 and R 2 is hydrogen, which comprises slurrying the keto acid with an alcohol solvent, maintaining the slurry at elevated temperature in a sealed vessel until the Rhodamine impurity has dissolved, cooling and isolating the pure keto acid by filtration.
公开/授权文献
- EP0853078B1 Purification process of keto acids 公开/授权日：2000-08-16
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