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    Purification process of keto acids
    2.
    发明公开
    Purification process of keto acids 失效
    Verfahren zur Reinigung vonKetosäuren

    公开(公告)号：EP0853078A1

    公开(公告)日：1998-07-15

    申请号：EP97309175.4

    申请日：1997-11-14

    申请人： Ciba Specialty Chemicals Holding Inc.

    发明人： Taylor, James Philip ,  Henshall, John Barry ,  Whitworth, John

    IPC分类号： C07C227/38 ,  C07C227/42 ,  C07C229/52

    CPC分类号： C07C227/38 ,  C07C229/52

    摘要： A method for the purification of a keto acid having the general formula


    wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl both of which may be substituted by at least one substituent selected from the group consisting of halogen atoms and alkyls having 1-4 carbon atoms, an aralkyl of 7-10 carbon atoms, alkoxyalkyl having 2-20 carbon atoms, tetrahydrofuryl alkyl, alkylcarboxy alkyl, alkyl carboxy benzyl, or R1 and R2 together with the adjacent nitrogen atom may form a heterocyclic ring, or one of R 1 and R 2 is hydrogen, which comprises slurrying the keto acid with an alcohol solvent, maintaining the slurry at elevated temperature in a sealed vessel until the Rhodamine impurity has dissolved, cooling and isolating the pure keto acid by filtration.

    摘要翻译： 一种用于纯化具有通式的酮酸的方法，其中R 1和R 2独立地表示1-18个碳原子的直链或支链烷基，4-8个碳原子的环烷基或两个可以 被至少一个选自卤素原子和具有1-4个碳原子的烷基，7-10个碳原子的芳烷基，具有2-20个碳原子的烷氧基烷基，烷基羧基烷基，烷基羧基烷基，烷基羧基苄基 ，或R 1和R 2与相邻的氮原子一起可以形成杂环，或者R 1和R 2之一是氢，其包括用醇溶剂将酮酸酸化，将浆液保持在高温下在密封容器中直到 罗丹明杂质溶解，冷却并通过过滤分离纯酮酸。

    Production of aminophenols
    5.
    发明公开
    Production of aminophenols 失效
    Herstellung von Aminophenolen

    公开(公告)号：EP0831081A1

    公开(公告)日：1998-03-25

    申请号：EP97307066.7

    申请日：1997-09-11

    申请人： Ciba Specialty Chemicals Holding Inc.

    发明人： Henshall, John Barry ,  Walsh, Steven ,  Whitworth, John ,  Dearden, Ian Antony

    IPC分类号： C07C213/08 ,  C07C215/76

    CPC分类号： C07C213/08 ,  C07C215/76

    摘要： A method of producing N,N-disubstituted aminophenols of the general formula
    wherein R 1 and R 2 are the same or different and each represents a saturated or unsaturated aliphatic hydrocarbyl, cycloalkyl, aralkyl,
    the phenyl ring of which may be further substituted, alkoxyalkyl, or a cycloalkylalkyl, except that R 1 and R 2 are not simultaneously methyl and R' represents hydrogen, halogen, nitro, cyano, alkyl or alkoxy, which comprises reacting an aminophenol of general formula
    wherein R 3 represents hydrogen or R 1 , and R' is as defined above, with an organic halide species of general formula R 2 X wherein R 2 is as defined above and X is halogen under aqueous acidic conditions with the periodic addition of an acid trapping agent in such a way that continuous monitoring of pH is not required.

    摘要翻译： 制备通式为CHEM的N，N-二取代氨基苯酚的方法，其中R 1和R 2相同或不同，并且各自表示饱和或不饱和的脂族烃基，环烷基，芳烷基，其苯基环可进一步被取代， 烷氧基烷基或环烷基烷基，除了R1和R2不同时为甲基，R'表示氢，卤素，硝基，氰基，烷基或烷氧基，其包括使通式为CHEM的氨基苯酚（其中R 3表示氢或R 1）与 R'如上定义，与具有通式R 2 X的有机卤化物类似，其中R2如上所定义，X是在酸性水溶液条件下的卤素，其中定期添加酸捕获剂，使得连续监测pH不是 需要。

    Process for the preparation on 3-(N,N-Dimethylamino)benzoic acid
    8.
    发明公开
    Process for the preparation on 3-(N,N-Dimethylamino)benzoic acid 失效
    Verfahren zur Herstellung von 3-（N，N-二甲基氨基） - 苯甲酸酯

    公开(公告)号：EP0855386A1

    公开(公告)日：1998-07-29

    申请号：EP97310316.1

    申请日：1997-12-19

    申请人： Ciba Specialty Chemicals Holding Inc.

    发明人： Henshall, John Barry ,  Whitworth, John

    IPC分类号： C07C227/18 ,  C07C227/04 ,  C07C229/60

    CPC分类号： C07C227/18 ,  C07C227/04 ,  C07C229/60

    摘要： The invention provides a process for the preparation of 3-(N,N-dimethylamino) benzoic acid which comprises subjecting an aqueous solution of an alkali metal salt or ammonium salt of 3-aminobenzoic acid to reductive methylation in the presence of a supported transition metal catalyst, by the controlled and continuous addition of a solution of formaldehyde over a period of 0.5 to 20 hours with a hydrogen pressure between 1 bar and 40 bar and with the temperature of the reaction mass gradually raised during the reduction, the reaction being carried out within the temperature range of 20 °C to 120 °C, and wherein a buffering agent is added such that the pH of the reaction mass after reductive methylation is from 6.5 to 9.5.

    摘要翻译： 本发明提供了制备3-（N，N-二甲基氨基）苯甲酸的方法，该方法包括在负载的过渡金属存在下使碱金属盐或3-氨基苯甲酸铵盐的水溶液还原甲基化 催化剂，通过在1巴和40巴之间的氢气压力下在0.5至20小时的时间内可控地和连续地加入甲醛溶液，并且在还原期间反应物质的温度逐渐升高，反应进行 在20〜120℃的温度范围内，添加缓冲剂使得还原性甲基化后的反应物质的pH为6.5〜9.5。