发明公开
EP0860432A1 2-Phenyl-2-(2'-piperidinylidene) acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2(2'-piperidinyl) acetate derivative by asymmetrically hydrogenating the same
失效
2-苯基-2-（2“哌啶基）乙酸酯衍生物，它们的制备方法，和通过不对称氢化光学活性的2-苯基-2-（2'-哌啶）乙酸乙酯衍生物的方法
- 专利标题： 2-Phenyl-2-(2'-piperidinylidene) acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2(2'-piperidinyl) acetate derivative by asymmetrically hydrogenating the same
- 专利标题（中）： 2-苯基-2-（2“哌啶基）乙酸酯衍生物，它们的制备方法，和通过不对称氢化光学活性的2-苯基-2-（2'-哌啶）乙酸乙酯衍生物的方法
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申请号： EP98400387.1申请日： 1998-02-18
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公开(公告)号： EP0860432A1公开(公告)日： 1998-08-26
- 发明人: Seido, Nobuo , Nishikawa, Takenobu , Sotoguchi, Tsukasa , Yuasa, Yoshifumi , Miura, Takashi , Kumobayashi, Hidenori
- 申请人： Takasago International Corporation
- 申请人地址： 19-22, Takanawa 3-chome Minato-ku Tokyo 108 JP
- 专利权人： Takasago International Corporation
- 当前专利权人： Takasago International Corporation
- 当前专利权人地址： 19-22, Takanawa 3-chome Minato-ku Tokyo 108 JP
- 代理机构： Uchida, Kenji
- 优先权： JP72570/97 19970219; JP117358/97 19970402
- 主分类号： C07D211/70
- IPC分类号： C07D211/70
摘要：
Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative of formula(1) suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative of formula(3)and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative which is a major intermediate for an antidepressant. The 2-phenyl-2-(2'-piperidinylidene)acetate derivative is manufactured by cyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoate derivative of formula(2). The optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative is manufactured by asymmetrically hydrogenating the 2-phenyl-2-(2'-piperidinylidene)acetate derivative in the presence of a complex of a Group VIII transition metal or an acid.
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