发明公开
- 专利标题： APOVINCAMINIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME
- 专利标题（中）： 阿朴氨酸衍生物和含有它的药物
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申请号： EP95938607.9申请日： 1995-11-29
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公开(公告)号： EP0864571A1公开(公告)日： 1998-09-16
- 发明人: HIDAKA, Hiroyoshi , ISHIKAWA, Tomohiko , MURAMATSU, Hiroshi , INOUE, Tsutomu
- 申请人： Hidaka, Hiroyoshi
- 申请人地址： 3-A, 607 Otokikiyama, Tenpaku-ku Nagoya-shi, Aichi 468 JP
- 专利权人： Hidaka, Hiroyoshi
- 当前专利权人： Hidaka, Hiroyoshi
- 当前专利权人地址： 3-A, 607 Otokikiyama, Tenpaku-ku Nagoya-shi, Aichi 468 JP
- 代理机构： Hansen, Bernd, Dr. Dipl.-Chem.
- 国际公布： WO9719945 19970605
- 主分类号： C07D461/00
- IPC分类号： C07D461/00 ; A61K31/435
摘要：
This invention relates to an apovincaminic acid derivative represented by the following formula (1):
wherein R 1 represents a lower alkyl group, and R 2 represents an aryl group, which may be substituted by 1 to 5 substituents selected from halogen atoms and lower alkyl, lower alkoxy, lower alkoxycarbonyl, acylamino and nitro groups, a benzyl group, a quinolyl group or a thienyl group, or an acid addition salt thereof; and also to a drug containing the same. This compound has excellent vasodilating activity and platelet aggregation inhibiting activity, and can be used for the treatment of cerebrovascular disorder, thromboembolism and chronic arterial occlusive diseases and also for the improvement of blood flow disturbances.
wherein R 1 represents a lower alkyl group, and R 2 represents an aryl group, which may be substituted by 1 to 5 substituents selected from halogen atoms and lower alkyl, lower alkoxy, lower alkoxycarbonyl, acylamino and nitro groups, a benzyl group, a quinolyl group or a thienyl group, or an acid addition salt thereof; and also to a drug containing the same. This compound has excellent vasodilating activity and platelet aggregation inhibiting activity, and can be used for the treatment of cerebrovascular disorder, thromboembolism and chronic arterial occlusive diseases and also for the improvement of blood flow disturbances.
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