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    Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation and pharmaceutical compositions containing them
    1.
    发明公开
    Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation and pharmaceutical compositions containing them 失效
    具有血管舒张作用和抑制血小板聚集的效果和含有它们的药物组合物的化合物。

    公开(公告)号：EP0416820A2

    公开(公告)日：1991-03-13

    申请号：EP90309530.5

    申请日：1990-08-31

    申请人： Hidaka, Hiroyoshi ,  TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA

    发明人： Hidaka, Hiroyoshi ,  Ishikawa, Tomohiko ,  Inoue, Tsutomu ,  Yuasa, Masayuki ,  Inaba, Takashi ,  Naito, Kenji ,  Sakuma, Osamu ,  Morita, Tadashi ,  Kidokoro, Shinpei

    IPC分类号： C07D495/04 ,  C07D495/14 ,  A61K31/435

    CPC分类号： C07D495/04 ,  C07D495/14

    摘要： Novel compounds represented by the formula:
    wherein R₁ represents an alkyl group having 1 to 3 carbon atoms, R₂ represents an amino group or a group of formula
    in which R₄ represents an alkyl group having 1 to 3 carbon atoms, R₅ represents an alkyl group having 1 to 3 carbon atoms or may combine with R₆ to form a five or six membered ring containing 4 to 5 carbon atoms, R₆ represents a hydrogen atom or may combine with R₅ to form a five or six membered ring containing 4 to 5 carbon atoms, R₃ represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation.
    Thus, they are useful as therapeutic agents for treat­ment of angina pectoris, hypertension, thrombosis and the like.

    摘要翻译： 由下式表示的新化合物： worin具有1至3个碳原子的烷基的R1 darstellt，氨基的R2 darstellt或下式基团的其中具有1至3个碳原子烷基的R4 darstellt， 具有1至3个碳原子，或者可以与R 6结合以形成五或六元环含4-5个碳原子的烷基的R 5 darstellt，R6代表氢原子或可以与R5结合形成五或六元环含 4至5个碳原子，R 3表示氢原子，在具有1-3个碳原子或卤素原子的烷基，X代表羰基或亚甲基，Y表示硫原子或亚乙烯基，其可药用盐 表现出对血小板聚集的血管舒张活性和抑制活性。 因此，它们是用于治疗心绞痛，高血压，血栓症等的治疗剂。

    Sydnonimine derivatives, process for production thereof, and use thereof
    2.
    发明公开
    Sydnonimine derivatives, process for production thereof, and use thereof 失效
    Sydnonimin-Derivate，Verfahren zu deren Herstellung und deren Verwendung。

    公开(公告)号：EP0073345A2

    公开(公告)日：1983-03-09

    申请号：EP82106796.4

    申请日：1982-07-27

    申请人： Hidaka, Hiroyoshi

    发明人： Hidaka, Hiroyoshi ,  Matsumoto, Ikuo ,  Yoshizawa, Junji ,  Kotani, Shigenori

    IPC分类号： C07D271/04 ,  A61K31/495

    CPC分类号： C07D295/28 ,  C07D271/04 ,  Y10S514/929

    摘要： A 3-[4-benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula
    wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n represents zero or an integer of 1 to 10,
    and its acid addition salt. The above sydnonimine compounds are useful for the treatment of troubles of the circulatory system and can be produced by contacting a 4-(benzoylalkyl)-1-(N-nitrosocyanomethylamino)piperazine represented by the following formula
    I wherein R and n are as defined, with an acid.

    摘要翻译： 由下式表示的3- [4-苯甲酰基烷基]哌嗪-1-基]次氨基亚胺化合物... 其中R表示氢原子或具有1至8个碳原子的烷基，n表示0或整数 为1〜10，...及其酸加成盐。 上述的sydnonimine化合物可用于治疗循环系统的麻烦，并且可以通过使由下式表示的4-（苯甲酰基烷基）-1-（N-亚硝基氰基甲基氨基）哌嗪与 与酸定义一致。

    APOVINCAMINIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME
    4.
    发明公开
    APOVINCAMINIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME 失效
    Apovincaminic衍生物及药物含有它们的

    公开(公告)号：EP0864571A4

    公开(公告)日：1998-12-02

    申请号：EP95938607

    申请日：1995-11-29

    申请人： HIDAKA HIROYOSHI

    发明人： HIDAKA HIROYOSHI ,  ISHIKAWA TOMOHIKO ,  MURAMATSU HIROSHI ,  INOUE TSUTOMU

    IPC分类号： C07D461/00 ,  A61K31/435

    CPC分类号： C07D461/00

    摘要： An apovincaminic acid derivative represented by general formula (I) or an acid-addition salt thereof and a medicine containing the same (wherein R1 represents lower alkyl; and R2 represents aryl optionally substituted by 1 to 5 substituents selected from among halogeno, lower alkyl, lower alkoxy, lower alkoxycarbonyl, acylamino and nitro, benzyl, quinolyl or thienyl), having excellent vasodilator and platelet aggregation inhibitory effects, and being usable in treating cerebrovascular disorders, thrombus formation/embolization and chronic arterial obliteration and ameliorating blood flow disorders.

    METHOD FOR IN VIVO DETECTING A TARGET PROTEIN GENE BY A DRUG
    8.
    发明授权
    METHOD FOR IN VIVO DETECTING A TARGET PROTEIN GENE BY A DRUG 失效
    PROCEDURE用于确定所述基因中的靶蛋白的使用的药物

    公开(公告)号：EP1072688B1

    公开(公告)日：2004-06-30

    申请号：EP98914021.5

    申请日：1998-04-15

    申请人： Hidaka, Hiroyoshi

    发明人： HIDAKA, Hiroyoshi ,  TANAKA, Hideki

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1048

    摘要： A method for in vivo detecting a target protein gene by a drug, which comprises binding an antigenic substance to a drug to be administered to a living organism via a chemical crosslinker, using the obtained material as a probe, and directly screening the gene of the protein bonded to the above probe by using a cDNA expression library containing genes of the living organism to which the drug is to be administered. Compared with the conventional drug-fixed column methods, the above method makes it possible to directly and conveniently isolate the gene of the target molecule without resort to the purification of the protein and the analysis of the amino acid sequence thereof.

    METHOD FOR IN VIVO DETECTING A TARGET PROTEIN GENE BY A DRUG
    9.
    发明公开
    METHOD FOR IN VIVO DETECTING A TARGET PROTEIN GENE BY A DRUG 失效
    PROCEDURE用于确定所述基因中的靶蛋白的使用的药物

    公开(公告)号：EP1072688A4

    公开(公告)日：2002-05-22

    申请号：EP98914021

    申请日：1998-04-15

    申请人： HIDAKA HIROYOSHI

    发明人： HIDAKA HIROYOSHI ,  TANAKA HIDEKI

    IPC分类号： G01N33/566 ,  C07D213/42 ,  C07H21/04 ,  C12N15/00 ,  C12N15/09 ,  C12N15/10 ,  C12Q1/68 ,  C12R1/91

    CPC分类号： C12N15/1048

    摘要： A method for in vivo detecting a target protein gene by a drug, which comprises binding an antigenic substance to a drug to be administered to a living organism via a chemical crosslinker, using the obtained material as a probe, and directly screening the gene of the protein bonded to the above probe by using a cDNA expression library containing genes of the living organism to which the drug is to be administered. Compared with the conventional drug-fixed column methods, the above method makes it possible to directly and conveniently isolate the gene of the target molecule without resort to the purification of the protein and the analysis of the amino acid sequence thereof.