发明公开
EP0867515A1 Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
失效
Verfahren zur Isolierung eines pharmazeutischverträglichenAlkalmetallsalzes derClavulansäure
- 专利标题： Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
- 专利标题（中）： Verfahren zur Isolierung eines pharmazeutischverträglichenAlkalmetallsalzes derClavulansäure
-
申请号： EP97104947.3申请日： 1997-03-24
-
公开(公告)号： EP0867515A1公开(公告)日： 1998-09-30
- 发明人: Cardoso, Jaoquim P.
- 申请人： CIPAN-Companhia Industrial Produtora De Antibioticos, S.A.
- 申请人地址： Vlal do Carregado, Apartado 60 2600 Castanheira do Ribatejo PT
- 专利权人： CIPAN-Companhia Industrial Produtora De Antibioticos, S.A.
- 当前专利权人： CIPAN-Companhia Industrial Produtora De Antibioticos, S.A.
- 当前专利权人地址： Vlal do Carregado, Apartado 60 2600 Castanheira do Ribatejo PT
- 代理机构： Godemeyer, Thomas, Dr.
- 主分类号： C12P17/18
- IPC分类号： C12P17/18 ; C07D503/00
摘要：
The invention relates to the process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid from a fermentation broth containing impure clavulanic acid comprising the steps of filtration of the fermented broth, extraction of the clavulanic acid to a water immiscible or partly water immiscible solvent at pH from 1.2 - 2, precipitation of an alkali metal salt A of clavulanic acid by addition of a solution of an alkali metal alkylalkanoate, characterized by the following steps:
before the filtration the fermented broth containing clavulanic acid is diluted with water, a flocculating agent is added and the pH is adjusted to 3 - 5
for further purification the alkali metal salt A of clavulanic acid is converted to clavulanic acid by addition of an inorganic acid and is extracted into a water immiscible or partly water immiscible solvent
a solution of a different alkali metal B alkyl alkanoate is added and the alkali metal salt B of clavulanic acid is precipitated.
before the filtration the fermented broth containing clavulanic acid is diluted with water, a flocculating agent is added and the pH is adjusted to 3 - 5
for further purification the alkali metal salt A of clavulanic acid is converted to clavulanic acid by addition of an inorganic acid and is extracted into a water immiscible or partly water immiscible solvent
a solution of a different alkali metal B alkyl alkanoate is added and the alkali metal salt B of clavulanic acid is precipitated.
公开/授权文献
信息查询
