利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.008 秒)

    Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
    3.
    发明公开
    Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid 失效
    Verfahren zur Isolierung eines pharmazeutischverträglichenAlkalmetallsalzes derClavulansäure

    公开(公告)号：EP0867515A1

    公开(公告)日：1998-09-30

    申请号：EP97104947.3

    申请日：1997-03-24

    申请人： CIPAN-Companhia Industrial Produtora De Antibioticos, S.A.

    发明人： Cardoso, Jaoquim P.

    IPC分类号： C12P17/18 ,  C07D503/00

    CPC分类号： C07D503/00 ,  C12P17/188

    摘要： The invention relates to the process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid from a fermentation broth containing impure clavulanic acid comprising the steps of filtration of the fermented broth, extraction of the clavulanic acid to a water immiscible or partly water immiscible solvent at pH from 1.2 - 2, precipitation of an alkali metal salt A of clavulanic acid by addition of a solution of an alkali metal alkylalkanoate, characterized by the following steps:

    before the filtration the fermented broth containing clavulanic acid is diluted with water, a flocculating agent is added and the pH is adjusted to 3 - 5
    for further purification the alkali metal salt A of clavulanic acid is converted to clavulanic acid by addition of an inorganic acid and is extracted into a water immiscible or partly water immiscible solvent
    a solution of a different alkali metal B alkyl alkanoate is added and the alkali metal salt B of clavulanic acid is precipitated.

    摘要翻译： 本发明涉及从含有不纯的克拉维酸的发酵液中分离可药用的克拉维酸碱金属盐的方法，包括以下步骤：过滤发酵肉汤，将克拉维酸萃取到与水不混溶或部分与水不混溶的水 溶剂，pH为1.2-2，通过加入碱金属烷基链烷酸酯的溶液沉淀棒酸的碱金属盐A，其特征在于以下步骤：在过滤之前，将含有克拉维酸的发酵肉汤用水稀释， 加入絮凝剂并将pH调节至3-5以进一步纯化，通过加入无机酸将克拉维酸的碱金属盐A转化为克拉维酸，并将其萃取到水不混溶或部分与水不混溶的溶剂中， 加入不同的碱金属B烷基链烷酸酯，并且克拉维酸的碱金属盐B沉淀 ated。