发明公开
EP0869120A1 Process for the preparation of nitroguanidine derivatives starting from 2-nitroimino-hexahydro-1,3,5-triazines in the presence of ammonia, primary or secondary amine
失效
一种制备由2-硝基亚氨基六氢-1,3,5-三嗪在氨，伯胺或仲胺的存在下起始的硝基胍衍生物的方法
- 专利标题： Process for the preparation of nitroguanidine derivatives starting from 2-nitroimino-hexahydro-1,3,5-triazines in the presence of ammonia, primary or secondary amine
- 专利标题（中）： 一种制备由2-硝基亚氨基六氢-1,3,5-三嗪在氨，伯胺或仲胺的存在下起始的硝基胍衍生物的方法
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申请号： EP98105850.6申请日： 1998-03-31
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公开(公告)号： EP0869120A1公开(公告)日： 1998-10-07
- 发明人: Ebihara, Koichi , Ura, Daisuke , Miyamoto, Michihiko , Kaiho, Tatsuo
- 申请人： MITSUI CHEMICALS, INC.
- 申请人地址： 2-5, Kasumigaseki 3-chome, Chiyoda-ku Tokyo JP
- 专利权人： MITSUI CHEMICALS, INC.
- 当前专利权人： MITSUI CHEMICALS, INC.
- 当前专利权人地址： 2-5, Kasumigaseki 3-chome, Chiyoda-ku Tokyo JP
- 代理机构： Zumstein, Fritz, Dr.
- 优先权： JP80178/97 19970331; JP82838/97 19970401; JP223813/97 19970820; JP258968/97 19970924; JP347934/97 19971217
- 主分类号： C07D213/61
- IPC分类号： C07D213/61 ; C07D277/32 ; C07D307/14
摘要：
Described is a convenient process, as a substitute for hydrolysis, for preparing a nitroguanidine derivative represented by the following formula (2):
wherein A represents a substituted or unsubstituted aromatic or non-aromatic hydrocarbon ring, a substituted or unsubstituted aromatic or non-aromatic heterocycle, a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl or alkynyl group; and R 2 represents a hydrogen atom, a substituted or unsubstituted C 1-6 alkyl, alkenyl or alkynyl group, which comprises reacting a compound represented by the following formula (1):
wherein R 1 represents a substituted or unsubstituted, linear or cyclic C 1-10 alkyl group and A and R 2 have the same meanings as defined above, with ammonia, a primary amine or a secondary amine, or a salt thereof.
wherein A represents a substituted or unsubstituted aromatic or non-aromatic hydrocarbon ring, a substituted or unsubstituted aromatic or non-aromatic heterocycle, a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl or alkynyl group; and R 2 represents a hydrogen atom, a substituted or unsubstituted C 1-6 alkyl, alkenyl or alkynyl group, which comprises reacting a compound represented by the following formula (1):
wherein R 1 represents a substituted or unsubstituted, linear or cyclic C 1-10 alkyl group and A and R 2 have the same meanings as defined above, with ammonia, a primary amine or a secondary amine, or a salt thereof.
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