发明公开
EP0885900A2 Increasing blood-brain barrier permeability with permeabilizer peptide derivatives of bradykinin
失效
通过使用透气性促进的增加血脑屏障的渗透性，从肽缓激肽衍生
- 专利标题： Increasing blood-brain barrier permeability with permeabilizer peptide derivatives of bradykinin
- 专利标题（中）： 通过使用透气性促进的增加血脑屏障的渗透性，从肽缓激肽衍生
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申请号： EP98113628.6申请日： 1992-04-23
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公开(公告)号： EP0885900A2公开(公告)日： 1998-12-23
- 发明人: Kozarich, John W. , Musso, Gary F. , Malfroy-Camine, Bernard
- 申请人： ALKERMES, INC.
- 申请人地址： 26 Landsdowne Street Cambridge, MA 02139-4234 US
- 专利权人： ALKERMES, INC.
- 当前专利权人： ALKERMES, INC.
- 当前专利权人地址： 26 Landsdowne Street Cambridge, MA 02139-4234 US
- 代理机构： Kirkham, Nicholas Andrew
- 优先权： US690522 19910423
- 主分类号： C07K7/02
- IPC分类号： C07K7/02 ; C07K7/18 ; A61K38/08 ; A61K47/42
摘要：
Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood/brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously coadministered to a host together with molecules whose desired destination is the interstitial fluid compartment of the brain. Alternatively, the permeabilizer A-7 or conformational analogues can be administered sequentially with the molecule(s) of interest and these molecules can also be administered by routes other than intravascular. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive in the interstitial fluid.
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