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1.发明公开Increasing blood-brain barrier permeability with permeabilizer peptide derivatives of bradykinin 失效通过使用透气性促进的增加血脑屏障的渗透性，从肽缓激肽衍生
公开(公告)号：EP0885900A3
公开(公告)日：2000-04-26
申请号：EP98113628.6
申请日：1992-04-23
申请人： ALKERMES, INC.
CPC分类号： A61K38/043 , A61K38/08 , A61K47/42 , C07K7/02 , C07K7/18 , Y10S514/929 , A61K2300/00
摘要： Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood/brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously coadministered to a host together with molecules whose desired destination is the interstitial fluid compartment of the brain. Alternatively, the permeabilizer A-7 or conformational analogues can be administered sequentially with the molecule(s) of interest and these molecules can also be administered by routes other than intravascular. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive in the interstitial fluid.
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2.发明公开Increasing blood-brain barrier permeability with permeabilizer peptide derivatives of bradykinin 失效通过使用透气性促进的增加血脑屏障的渗透性，从肽缓激肽衍生
公开(公告)号：EP0885900A2
公开(公告)日：1998-12-23
申请号：EP98113628.6
申请日：1992-04-23
申请人： ALKERMES, INC.
CPC分类号： A61K38/043 , A61K38/08 , A61K47/42 , C07K7/02 , C07K7/18 , Y10S514/929 , A61K2300/00
摘要： Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood/brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously coadministered to a host together with molecules whose desired destination is the interstitial fluid compartment of the brain. Alternatively, the permeabilizer A-7 or conformational analogues can be administered sequentially with the molecule(s) of interest and these molecules can also be administered by routes other than intravascular. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive in the interstitial fluid.
摘要翻译： 肽称为受体介导的permeabilizers（RMP）增加血/脑屏障的分子的渗透性：如治疗剂或诊断剂。 所述渗透剂A-7或构象的类似物可经静脉内连同分子，其希望的目的地是脑的间质液隔室共同施用至宿主。 可替代地，渗透剂A-7或构象类似物可与兴趣和合成分子的分子（多个）被依次施用因此，可以通过血管内比其它途径给药。 所述渗透剂A-7或构象类似物允许合成分子穿透血 - 脑屏障，并在间质液到达。
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