发明公开
EP0891331A1 N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY
失效
N-（2-氧代乙酰基或磺酰基）-pyrrolidines具有改进多药耐药性活性/哌啶-2-羧酸衍生物
- 专利标题： N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY
- 专利标题（中）： N-（2-氧代乙酰基或磺酰基）-pyrrolidines具有改进多药耐药性活性/哌啶-2-羧酸衍生物
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申请号： EP97916231.0申请日： 1997-03-24
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公开(公告)号： EP0891331A1公开(公告)日： 1999-01-20
- 发明人: ARMISTEAD, David, M. , SAUNDERS, Jeffrey, O.
- 申请人： VERTEX PHARMACEUTICALS INCORPORATED
- 申请人地址： 130 Waverly Street Cambridge, MA 02139-4242 US
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： 130 Waverly Street Cambridge, MA 02139-4242 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US19960626259 19960329
- 国际公布： WO1997036869 19971009
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61K38 ; A61K45 ; A61P35 ; A61P43 ; C07D211 ; C07D401 ; C07D405 ; C07D409
摘要：
The present invention relates to compounds of formula (I) and (II) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
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