发明授权
EP0892790B1 NEW QUINAZOLINE-4-AMINO-2-(PIPERIDINE-1-YL-4-SUBSTITUTED) DERIVATIVES HAVING ANTI-HYPERTENSIVE ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
失效
（2-哌啶-1-基-4-取代）-4-氨基-2- WITH降压作用，PROCESS FOR其制备方法及其药物用途 - 喹唑啉衍生物
- 专利标题： NEW QUINAZOLINE-4-AMINO-2-(PIPERIDINE-1-YL-4-SUBSTITUTED) DERIVATIVES HAVING ANTI-HYPERTENSIVE ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
- 专利标题（中）： （2-哌啶-1-基-4-取代）-4-氨基-2- WITH降压作用，PROCESS FOR其制备方法及其药物用途 - 喹唑啉衍生物
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申请号： EP96928398.5申请日： 1996-07-31
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公开(公告)号： EP0892790B1公开(公告)日： 2004-04-14
- 发明人: MAKOVEC, Francesco , PERIS, Walter , ROVATI, Lucio, Claudio , ROVATI, Luigi, Angelo
- 申请人： ROTTA RESEARCH LABORATORIUM S.P.A.
- 申请人地址： Galleria Unione, 5 20122 Milano IT
- 专利权人： ROTTA RESEARCH LABORATORIUM S.P.A.
- 当前专利权人： ROTTA RESEARCH LABORATORIUM S.P.A.
- 当前专利权人地址： Galleria Unione, 5 20122 Milano IT
- 代理机构： Rambelli, Paolo
- 优先权： ITTO960275 19960410
- 国际公布： WO1997037979 19971016
- 主分类号： C07D239/95
- IPC分类号： C07D239/95 ; A61K31/505 ; C07D407/12 ; C07D409/12 ; C07D403/12 ; A61K31/495
摘要：
New quinazolines are described having anti-hypertensive activity of general formula (I), in which Ar is : an unsubstituted phenyl group or a phenyl group mono-substituted with a methoxy, ethoxy or methyl group ; an unsubstituted pyridyl group (2-, 3- or 4-yl) or a pyridyl group mono-substituted with a methoxy or methyl group ; an unsubstituted furyl group (2- or 3-yl) or a furyl group substituted with a methoxy or methyl group ; a benzofuryl group (2- or 3-yl) ; an indolyl group (2- or 3-yl) ; a thiophenyl group (2- or 3-yl) ; a naphthyl group (1- or 2-yl) and their salts obtained from pharmaceutically acceptable inorganic or organic acids.
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