发明公开
- 专利标题： PEPTIDE ANTAGONISTS DERIVED FROM THE TRANSMEMBRANE DOMAINS OF G PROTEIN-COUPLED RECEPTORS
- 专利标题（中）： 由G蛋白偶联受体衍生的肽具有拮抗作用
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申请号： EP97916291.0申请日： 1997-04-21
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公开(公告)号： EP0901525A2公开(公告)日： 1999-03-17
- 发明人: BOUVIER, Michel , LOISEL, Thomas, P. , HEBERT, Terence E., Montreal Cardiology Unit Inst.
- 申请人： L'UNIVERSITE DE MONTREAL
- 申请人地址： Case postale 6128, Station Centre Ville Montréal, Québec H3C 3S7 CA
- 专利权人： L'UNIVERSITE DE MONTREAL
- 当前专利权人： L'UNIVERSITE DE MONTREAL
- 当前专利权人地址： Case postale 6128, Station Centre Ville Montréal, Québec H3C 3S7 CA
- 代理机构： Ziebig, Marlene, Dr. Dipl.-Chem.
- 优先权： US19960015891P 19960422
- 国际公布： WO1997040148 19971030
- 主分类号： C07K14
- IPC分类号： C07K14 ; C12N15 ; A61K38
摘要：
This invention relates to peptides and peptidomimetic compounds that act as antagonists against G protein-coupled receptors (GPCRs). Novel short peptides, derived from the transmembrane domains of GPCRs, ranging in size from about 15-20 amino acid residues, can be used as model peptides (peptide-leads) to design novel peptides and peptidiomimetic compounds that antagonize the activity of the same or closely related GPCRs from which they are derived. A lead peptide which may also be a preferred peptide antagonist for the human β2-adrenergic receptor is NH2-GIIMGTFTLCWLPFFIVNIVH-COOH.
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