专利检索 ap:("L'UNIVERSITE DE MONTREAL") AND inv:"LOISEL, Thomas, P." 第 1 页

1.

发明公开
PEPTIDE ANTAGONISTS DERIVED FROM THE TRANSMEMBRANE DOMAINS OF G PROTEIN-COUPLED RECEPTORS 失效
标题翻译：由G蛋白偶联受体衍生的肽具有拮抗作用

公开(公告)号：EP0901525A2

公开(公告)日：1999-03-17

申请号：EP97916291.0

申请日：1997-04-21

申请人： L'UNIVERSITE DE MONTREAL

发明人： BOUVIER, Michel , LOISEL, Thomas, P. , HEBERT, Terence E., Montreal Cardiology Unit Inst.

IPC分类号： C07K14 , C12N15 , A61K38

CPC分类号： C07K14/70571 , A61K38/00

摘要： This invention relates to peptides and peptidomimetic compounds that act as antagonists against G protein-coupled receptors (GPCRs). Novel short peptides, derived from the transmembrane domains of GPCRs, ranging in size from about 15-20 amino acid residues, can be used as model peptides (peptide-leads) to design novel peptides and peptidiomimetic compounds that antagonize the activity of the same or closely related GPCRs from which they are derived. A lead peptide which may also be a preferred peptide antagonist for the human β2-adrenergic receptor is NH2-GIIMGTFTLCWLPFFIVNIVH-COOH.