发明公开
EP0909392A1 METHOD OF ELECTRON SPIN RESONANCE ENHANCED MAGNETIC RESONANCE IMAGING (ESREMRI) WITH EX VIVO DYNAMIC NUCLEAR POLARISATON OF AN MR IMAGING AGENT
失效
METHODS FOR改进的磁性电子自旋共振图（ESREMRI）WITH DYNAMIC EX VIVO核极化磁PICTURE物质的
- 专利标题： METHOD OF ELECTRON SPIN RESONANCE ENHANCED MAGNETIC RESONANCE IMAGING (ESREMRI) WITH EX VIVO DYNAMIC NUCLEAR POLARISATON OF AN MR IMAGING AGENT
- 专利标题（中）： METHODS FOR改进的磁性电子自旋共振图（ESREMRI）WITH DYNAMIC EX VIVO核极化磁PICTURE物质的
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申请号： EP97930621.0申请日： 1997-07-03
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公开(公告)号： EP0909392A1公开(公告)日： 1999-04-21
- 发明人: LEUNBACH, Ib , YOUNG, Ian, The Robert Steiner MRI Unit , EHNHOLM, Gösta , HANSSON, Georg , PETERSSON, Stefan , WISTRAND, Lars-Goran , GOLMAN, Klaes
- 申请人： NYCOMED IMAGING AS
- 申请人地址： Nycoveien 2, P.O. Box 4220, Torshov 0401 Oslo 4 NO
- 专利权人： NYCOMED IMAGING AS
- 当前专利权人： NYCOMED IMAGING AS
- 当前专利权人地址： Nycoveien 2, P.O. Box 4220, Torshov 0401 Oslo 4 NO
- 代理机构： Cockbain, Julian, Dr.
- 优先权： GB19960014139 19960705
- 国际公布： WO1998001766 19980115
- 主分类号： B82B1
- IPC分类号： B82B1 ; A61B5 ; G01N24 ; G01R33
摘要：
The invention relates to a method of electron spin resonance enhanced magnetic resonance imaging comprising the steps of: (i) placing a composition comprising a contrast agent and an MR imaging agent in a first magnetic field; (ii) exciting ESR transitions in the contrast agent to generate dynamic nuclear polarisation of th e MR imaging agent; (iii) separating the contrast agent from the MR imaging agent; (iv) administering the MR imaging agent to the sample; (v) exciting NMR transitions of the MR imaging agent is a second magnetic field; and (vi) detecting MR response signals from the sample.
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