Preventives and/or remedies for multiple organ failure containing as the active ingredient tumor cytotoxic factor-II (TCF-II) or hepatocyte growth factor (HGF). These drugs are useful in preventing and/or treating deterioration in the general status due to burn, disseminated intravascular coagulation (DIC), circularity failure, hemorrhagis shock, infectious diseases, acute pancreatitis, ischemic injury, hepatorenal syndrome, hemorrhage of digestive tract, nutritional metabolic failure, cancer at the terminal stage, acquired immunodeficiency syndrome (AIDS), radiation injury, etc. and the progression from cachexy, etc. to multiple organ failure.