公开(公告)号：EP0914829A4

公开(公告)日：2004-06-16

申请号：EP98907158

申请日：1998-03-11

申请人： DAIICHI SEIYAKU CO

发明人： ARISAWA HIROHIKO ,  MASUNAGA HIROAKI ,  OGAWA HIROMI ,  HIGASHIO KANJI

IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/27 ,  A61P43/00 ,  C07K14/475 ,  C07K14/525 ,  A61K38/22

CPC分类号： A61K38/1833 ,  Y10S514/97

摘要： Preventives and/or remedies for multiple organ failure containing as the active ingredient tumor cytotoxic factor-II (TCF-II) or hepatocyte growth factor (HGF). These drugs are useful in preventing and/or treating deterioration in the general status due to burn, disseminated intravascular coagulation (DIC), circularity failure, hemorrhagis shock, infectious diseases, acute pancreatitis, ischemic injury, hepatorenal syndrome, hemorrhage of digestive tract, nutritional metabolic failure, cancer at the terminal stage, acquired immunodeficiency syndrome (AIDS), radiation injury, etc. and the progression from cachexy, etc. to multiple organ failure.

公开(公告)号：EP1142575A4

公开(公告)日：2002-07-24

申请号：EP00900360

申请日：2000-01-13

申请人： DAIICHI SEIYAKU CO

发明人： HAYASHI KEIJI ,  ARISAWA HIROHIKO ,  MASUNAGA HIROAKI

IPC分类号： A61K31/00 ,  A61K31/435 ,  A61K31/439 ,  A61P17/00 ,  A61P17/16 ,  C07D497/20

CPC分类号： C07D497/20

摘要： Novel dry skin remedies useful for the treatment of dry skin, containing as the active ingredient spiro[oxathiolane-quinuclidine] derivatives represented by general formula (I) or acid addition salts thereof, desirably cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride. The remedies promote the secretion of sebaceous and sweat glands through oral or parenteral administration to treat dry skin, thus being useful as drugs.