发明公开
EP0915869A1 NOVEL TRICYCLIC N-CYANOIMINES USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
失效
TRICYCLISCHE N-CYANOIMINE ALS INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE
- 专利标题： NOVEL TRICYCLIC N-CYANOIMINES USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
- 专利标题（中）： TRICYCLISCHE N-CYANOIMINE ALS INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE
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申请号： EP97934269.0申请日： 1997-07-29
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公开(公告)号： EP0915869A1公开(公告)日： 1999-05-19
- 发明人: COOPER, Alan, B. , WANG, James, J.-S. , LOVEY, Raymond, G. , DESAI, Jagdish, A. , SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, M. , DOLL, Ronald, J.
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 代理机构： Ritter, Stephen David
- 优先权： US19960690522 19960731
- 国际公布： WO1998004545 19980205
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P35 ; A61P43 ; C07D401 ; C07D405 ; C07D471 ; C07D521
摘要：
Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic N-cyanoimines compound to a biological system. In particular, the method inhibits the abnormal growth of cells in mammals such as a human.
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