发明授权
- 专利标题： LABELLED ELASTASE INHIBITORS
- 专利标题（中）： MARKED弹性蛋白酶抑制剂
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申请号： EP97940242.7申请日： 1997-09-10
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公开(公告)号： EP0927049B1公开(公告)日： 2005-05-11
- 发明人: BARNES, Karen Jane , BOWER, Gary Robert , FORSTER, Alan Michael Amersham plc , KNOX, Peter , MENDIZABAL, Marivi Amersham plc , STOREY, Anthony Eamon Amersham plc
- 申请人： Amersham plc
- 申请人地址： Amersham Place Little Chalfont Buckinghamshire HP7 9NA GB
- 专利权人： Amersham plc
- 当前专利权人： Amersham plc
- 当前专利权人地址： Amersham Place Little Chalfont Buckinghamshire HP7 9NA GB
- 代理机构： Canning, Lewis R.
- 优先权： EP96306718 19960916
- 国际公布： WO1998010800 19980319
- 主分类号： A61K51/08
- IPC分类号： A61K51/08 ; A61K49/00 ; A61K51/04
摘要：
A human leucocyte elastase (HLE) inhibitor labelled with a detector moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, is useful for the diagnostic imaging of sites of inflammation or infection in vivo, for labelling leucocytes in vitro, or for radiotherapy of arthritis. The HLE inhibitor is preferably a β-lactam or an azetidinone.
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