公开(公告)号：EP0927049B1

公开(公告)日：2005-05-11

申请号：EP97940242.7

申请日：1997-09-10

申请人： Amersham plc

发明人： BARNES, Karen Jane ,  BOWER, Gary Robert ,  FORSTER, Alan Michael Amersham plc ,  KNOX, Peter ,  MENDIZABAL, Marivi Amersham plc ,  STOREY, Anthony Eamon Amersham plc

IPC分类号： A61K51/08 ,  A61K49/00 ,  A61K51/04

CPC分类号： A61K51/088 ,  A61K49/085 ,  A61K49/14 ,  A61K51/0444 ,  A61K51/0455 ,  A61K51/0459 ,  A61K2121/00 ,  A61K2123/00

摘要： A human leucocyte elastase (HLE) inhibitor labelled with a detector moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, is useful for the diagnostic imaging of sites of inflammation or infection in vivo, for labelling leucocytes in vitro, or for radiotherapy of arthritis. The HLE inhibitor is preferably a β-lactam or an azetidinone.