发明公开
- 专利标题： MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME
- 专利标题（中）： 黑色素瘤，免疫黑色素瘤抗原部件和申请流程。
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申请号： EP97936164.0申请日： 1997-08-04
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公开(公告)号： EP0929318A2公开(公告)日： 1999-07-21
- 发明人: PARDOLL, Drew, M. , JAFFEE, Elizabeth, M. , ADLER, Adam , TOPALIAN, Suzanne, L. , ROSENBERG, Steven, A.
- 申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , THE UNITED STATES OF AMERICA
- 申请人地址： 720 Rutland Avenue Baltimore, MD 21205 US
- 专利权人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE,THE UNITED STATES OF AMERICA
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE,THE UNITED STATES OF AMERICA
- 当前专利权人地址： 720 Rutland Avenue Baltimore, MD 21205 US
- 代理机构： Hoeger, Stellrecht & Partner
- 优先权： US19960024098P 19960816
- 国际公布： WO1998006746 19980219
- 主分类号： A61K48
- IPC分类号： A61K48 ; A61K35 ; A61K39 ; A61P35
摘要：
The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a citokyne relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogenic and is not MHC-matched to the host.
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