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1.发明授权MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME 失效黑色素瘤，免疫黑色素瘤抗原部件和申请流程。
公开(公告)号：EP0929318B1
公开(公告)日：2004-11-24
申请号：EP97936164.9
申请日：1997-08-04
发明人： PARDOLL, Drew, M. , JAFFEE, Elizabeth, M. , ADLER, Adam , TOPALIAN, Suzanne, L. , ROSENBERG, Steven, A.
CPC分类号： A61K39/0011 , A61K39/00 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a citokyne relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogenic and is not MHC-matched to the host.
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2.发明公开MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME 失效黑色素瘤，免疫黑色素瘤抗原部件和申请流程。
公开(公告)号：EP0929318A2
公开(公告)日：1999-07-21
申请号：EP97936164.0
申请日：1997-08-04
发明人： PARDOLL, Drew, M. , JAFFEE, Elizabeth, M. , ADLER, Adam , TOPALIAN, Suzanne, L. , ROSENBERG, Steven, A.
CPC分类号： A61K39/0011 , A61K39/00 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a citokyne relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogenic and is not MHC-matched to the host.
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公开(公告)号：EP0869803B1
公开(公告)日：2003-04-16
申请号：EP96945109.5
申请日：1996-12-26
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
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公开(公告)号：EP0869803A1
公开(公告)日：1998-10-14
申请号：EP96945109.0
申请日：1996-12-26
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
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