发明公开
- 专利标题: AMORPHOUS PAROXETINE COMPOSITION
- 专利标题(中): 非晶帕罗西汀ZUSAMMENSETZUNGEN
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申请号: EP97939837申请日: 1997-09-08
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公开(公告)号: EP0931080A4公开(公告)日: 2001-01-24
- 发明人: RONSEN BRUCE , EL-RASHIDY RAGAB
- 申请人: PENTECH PHARMACEUTICALS INC
- 专利权人: PENTECH PHARMACEUTICALS INC
- 当前专利权人: PENTECH PHARMACEUTICALS INC
- 优先权: US70880296 1996-09-09
- 主分类号: C07D405/12
- IPC分类号: C07D405/12 ; A61K31/435 ; A61K31/4525 ; A61P15/10 ; C07D401/12 ; C07D405/02
摘要:
A free-flowing, amorphous paroxetine hydrochloride-ethanol composition suitable as a therapeutic agent for premature ejaculation can be prepared by dissolving paroxetine free base in a hydrochloric acid-ethanol solution followed by drying. In a preferred embodiment, the amount of ethanol present in the amorphous product is in the range of 1 to 4 weight percent based on paroxetine hydrochloride. The amorphous product is stable and substantially non-hygroscopic.
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