发明公开
- 专利标题： INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
- 专利标题（中）： 蛋白法尼基转移酶抑制剂
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申请号： EP97921256.0申请日： 1997-03-27
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公开(公告)号： EP0944388A2公开(公告)日： 1999-09-29
- 发明人: ANTHONY, Neville, J. , DINSMORE, Christopher , GOMEZ, Robert, P. , HUTCHINSON, John, H. , WAI, John, S. , WILLIAMS, Theresa, M. , BELL, Ian, M. , EMBREY, Mark, W. , FISHER, Thorsten, E.
- 申请人： MERCK & CO., INC.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 代理机构： Thompson, John Dr., et al
- 优先权： US19960014791P 19960403; GB19960009981 19960513
- 国际公布： WO1997038665 19971023
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P9 ; A61P13 ; A61P27 ; A61P31 ; A61P35 ; A61P43 ; C07D211 ; C07D401 ; C07D413
摘要：
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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