发明公开
- 专利标题： INTEGRIN ANTAGONISTS
- 专利标题（中）： 整联蛋白拮抗剂
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申请号： EP97947280.0申请日： 1997-10-27
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公开(公告)号： EP0946165A1公开(公告)日： 1999-10-06
- 发明人: DUGGAN, Mark, E. , HARTMAN, George, D.
- 申请人： MERCK & CO., INC.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 代理机构： Horgan, James Michael Frederic, et al
- 优先权： US19960027867P 19961030; GB19960025805 19961212
- 国际公布： WO1998018460 19980507
- 主分类号： C07D235
- IPC分类号： C07D235 ; A61K31 ; A61K45 ; A61P9 ; A61P19 ; A61P35 ; A61P43 ; C07D213 ; C07D401 ; C07D471
摘要：
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are αvβ3 antagonists, αvβ5 antagonists or dual αvβ3/αvβ5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
公开/授权文献
- EP0946165B1 INTEGRIN ANTAGONISTS 公开/授权日：2003-04-09
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