发明公开
EP0950100A1 KERATINOCYTE GROWTH FACTOR-2 (KGF-2 OR FIBROBLAST GROWTH FACTOR-12, FGF-12)
无效
角质细胞生长因子的突变体-2（KGF-2或成纤维细胞生长因子12，FGF-12）
- 专利标题： KERATINOCYTE GROWTH FACTOR-2 (KGF-2 OR FIBROBLAST GROWTH FACTOR-12, FGF-12)
- 专利标题（中）： 角质细胞生长因子的突变体-2（KGF-2或成纤维细胞生长因子12，FGF-12）
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申请号： EP97937200.0申请日： 1997-08-13
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公开(公告)号： EP0950100A1公开(公告)日： 1999-10-20
- 发明人: DUAN, Roxanne , RUBEN, Steven, M. , JIMENEZ, Pablo , RAMPY, Mark, A. , MENDRICK, Donna , ZHANG, Jun , NI, Jian , MOORE, Paul, A. , COLEMAN, Timothy, A. , GENTZ, Reiner L.
- 申请人： HUMAN GENOME SCIENCES, INC.
- 申请人地址： 9410 Key West Avenue Rockville, MD 20850-3338 US
- 专利权人： HUMAN GENOME SCIENCES, INC.
- 当前专利权人： HUMAN GENOME SCIENCES, INC.
- 当前专利权人地址： 9410 Key West Avenue Rockville, MD 20850-3338 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US19960023852P 19960813; US19970039045P 19970228
- 国际公布： WO1998006844 19980219
- 主分类号： C12N15
- IPC分类号： C12N15 ; A61K38 ; A61P1 ; A61P3 ; A61P7 ; A61P9 ; A61P11 ; A61P13 ; A61P15 ; A61P17 ; A61P29 ; A61P31 ; A61P37 ; A61P43 ; C07K14 ; C12N5 ; A61K48
摘要：
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as 'KGF-2' also formerly known as Fibroblast Growth Factor 12 (FGF-12). The invention also relates to inhibiting the action of such polypeptides. This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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