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公开(公告)号：EP1187842B1
公开(公告)日：2006-04-26
申请号：EP00936337.5
申请日：2000-05-26
发明人： ROSEN, Craig, A. , NI, Jian
CPC分类号： C07K14/70578 , A61K38/17 , A61K48/00 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12N2799/026
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2.发明公开NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：EP1507793A2
公开(公告)日：2005-02-23
申请号：EP02786413.1
申请日：2002-10-16
发明人： YU, Guo-Liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , LAIRD, Michael, W. , ULLRICH, Stephen
CPC分类号： A61K51/08 , A61K38/00 , C07K14/525
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译： 本发明涉及编码嗜中性因子-α和/或中性因子-αSV多肽的核酸分子，包括可溶形式的胞外域。 还提供了中性因子-α和/或中性因子-αSV多肽以及载体，宿主细胞和用于产生它们的重组方法。 本发明还涉及特异性结合中性因子-α和/或中性因子-αSV的抗体或其部分以及使用这些抗体的诊断和治疗方法。 还提供了用于检测免疫系统相关病症的诊断方法和使用本发明组合物治疗免疫系统相关病症的治疗方法。
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公开(公告)号：EP1357931A2
公开(公告)日：2003-11-05
申请号：EP02736471.0
申请日：2002-01-04
发明人： RUBEN, Steven, M. , JIMENEZ, Pablo , DUAN, D., Roxanne , RAMPY, Mark, A. , MENDRICK, Donna , ZHANG, Jun , NI, Jian , MOORE, Paul, A. , COLEMAN, Timothy, A. , GRUBER, Joachim R. , DILLON, Patrick, J. , GENTZ, Reiner, L.
CPC分类号： C07K14/50 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as 'KGF-2' also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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公开(公告)号：EP1325021A1
公开(公告)日：2003-07-09
申请号：EP01910338.1
申请日：2001-01-17
发明人： ROSEN, Craig, A. , KOMATSOULIS, George, A. , BAKER, Kevin, P. , BIRSE, Charles, E. , SOPPET, Daniel, R. , OLSEN, Henrik, S. , MOORE, Paul, A. , WEI, Ping , EBNER, Reinhard , DUAN, D., Roxanne , SHI, Yanggu , CHOI, Gil, H. , FISCELLA, Michele , NI, Jian
IPC分类号： C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C12Q1/68 , C12N1/21 , C12N15/63 , C12N15/85 , C12N15/86
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：EP1322659A1
公开(公告)日：2003-07-02
申请号：EP01985257.3
申请日：2001-01-17
发明人： ROSEN, Craig, A. , KOMATSOULIS, George, A. , BAKER, Kevin, P. , BIRSE, Charles, E. , SOPPET, Daniel, R. , OLSEN, Henrik, S. , MOORE, Paul, A. , WEI, Ping , EBNER, Reinhard , DUAN, D., Roxanne , SHI, Yanggu , CHOI, Gil, H. , FISCELLA, Michele , NI, Jian
IPC分类号： C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C12Q1/68 , C12N1/21 , C12N15/63 , C12N15/85 , C12N15/86
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及新的人分泌蛋白和含有编码这些蛋白的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白的载体，宿主细胞，抗体和重组方法。 本发明进一步涉及诊断和治疗方法，用于诊断和治疗与这些新的人类分泌蛋白相关的疾病，病症和/或病症。
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公开(公告)号：EP1322657A1
公开(公告)日：2003-07-02
申请号：EP01914333.8
申请日：2001-01-17
发明人： ROSEN, Craig, A. , KOMATSOULIS, George, A. , BAKER, Kevin, P. , BIRSE, Charles, E. , SOPPET, Daniel, R. , OLSEN, Henrik, S. , MOORE, Paul, A. , WEI, Ping , EBNER, Reinhard , DUAN, D., Roxanne , SHI, Yanggu , CHOI, Gil, H. , FISCELLA, Michele , NI, Jian
IPC分类号： C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C12Q1/68 , C12N1/21 , C12N15/63 , C12N15/85 , C12N15/86
CPC分类号： C12Q1/6876 , A61K38/00 , C07K14/47 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：EP1261635A1
公开(公告)日：2002-12-04
申请号：EP01911042.8
申请日：2001-02-22
发明人： NI, Jian , SHI, Yanggu , EBNER, Reinhard , CHOI, Gil, H. , RUBEN, Steven, M.
CPC分类号： C07K14/47
摘要： The present invention relates to novel human polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing the human polypeptides of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human polypeptides.
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公开(公告)号：EP1259527A1
公开(公告)日：2002-11-27
申请号：EP00978417.4
申请日：2000-11-08
IPC分类号： C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C12Q1/68 , C12N1/21 , C12N15/63 , C12N15/85 , C12N15/86
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：EP1237901A1
公开(公告)日：2002-09-11
申请号：EP00976756.7
申请日：2000-11-01
IPC分类号： C07H21/04 , C07H21/02 , C07K5/00 , C07K14/00 , C12Q1/68 , C12N1/21 , C12N15/63 , C12N15/85 , C12N15/86
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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10.发明公开
公开(公告)号：EP1235837A1
公开(公告)日：2002-09-04
申请号：EP00980299.2
申请日：2000-11-08
发明人： NI, Jian , MOORE, Paul, A. , RUBEN, Steven, M.
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel human KDC polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human KDC polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human KDC polypeptides.
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