- 专利标题： INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
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申请号： EP97953451.0申请日： 1997-12-22
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公开(公告)号： EP0951285A1公开(公告)日： 1999-10-27
- 发明人: YOUNG, Steven, D. , ANTHONY, Neville, J. , GRAHAM, Samuel, L. , TRAN, Lekhanh, O. , BELL, Ian, M. , deSOLMS, S., Jane , GOMEZ, Robert, P. , KUO, Michelle, Sparks , LUMMA, William, C., Jr. , PERLOW, Debra, S. , SHAW, Anthony, W. , WAI, John, S.
- 申请人： MERCK & CO., INC.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 代理机构： Thompson, John Dr., et al
- 优先权： US19960033990P 19961230; GB19970002211 19970204
- 国际公布： WO1998029119 19980709
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P9 ; A61P13 ; A61P27 ; A61P31 ; A61P35 ; A61P43 ; C07D401 ; C07D403 ; C07D405 ; C07D417 ; C07D471
摘要：
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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