发明授权
EP0959899B1 LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION
失效
LO-CD2a抗体，以及它们对于T细胞活化和增殖的抑制使用
- 专利标题： LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION
- 专利标题（中）： LO-CD2a抗体，以及它们对于T细胞活化和增殖的抑制使用
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申请号： EP96930529.1申请日： 1996-08-16
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公开(公告)号： EP0959899B1公开(公告)日： 2009-05-27
- 发明人: BAZIN, Hervé , LATINNE, Dominique , KAPLAN, Ruth , KIEBER-EMMONS, Thomas , POSTEMA, Christina, E. , WHITE-SCHARF, Mary, E.
- 申请人： BIOTRANSPLANT, INC , University Catholique de Louvain
- 申请人地址： Bldg. 75, Third Avenue, Charlestown Navy Yard Charlestown, MA 02129 US
- 专利权人： BIOTRANSPLANT, INC,University Catholique de Louvain
- 当前专利权人： BIOTRANSPLANT, INC,University Catholique de Louvain
- 当前专利权人地址： Bldg. 75, Third Avenue, Charlestown Navy Yard Charlestown, MA 02129 US
- 代理机构： LOUIS, PÖHLAU, LOHRENTZ
- 国际公布： WO1998007444 19980226
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; A61K38/00 ; A61K38/16 ; C07K14/00 ; C07K16/00 ; C07K16/18 ; C07K16/28 ; C07K16/44 ; C07K16/46 ; C12P21/08
摘要：
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
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