发明公开
- 专利标题: Di-or triaza-spiro(4,5)decane derivatives
- 专利标题(中): 二 - 奥得三氮杂螺[4.5] decanderivate
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申请号: EP99110954.7申请日: 1999-06-07
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公开(公告)号: EP0963985A3公开(公告)日: 2001-01-24
- 发明人: Adam, Geo , Cesura, Andrea , Jenck, Francois , Kolczewski, Sabine , Roever, Stephan , Wichmann, Jürgen
- 申请人: F. HOFFMANN-LA ROCHE AG
- 申请人地址: 4070 Basel CH
- 专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人地址: 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: EP98110803 19980612
- 主分类号: C07D471/10
- IPC分类号: C07D471/10 ; A61K31/44 ; C07D513/10 ; C07D498/10
摘要:
The present invention relates to compounds of the general formula wherein R 1 is C 6 - 10 -cycloalkyl, optionally substituted by lower alkyl or -C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R 2 is hydrogen; lower alkyl; =O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; A○ is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; X is -CH(OH)-; -C(O)-; -CHR 3 -; -CR 3 =; -O-; -S-; -CH(COOR 4 )- or - C(COOR 4 )=; Y is -CH 2 -; -CH=; -CH(COOR 4 )-, -C(COOR 4 )=; or -C(CN)-; R 3 is hydrogen or lower alkoxy; R 4 is lower alkyl, cycloalkyl, phenyl, or benzyl and either a or b is optionally an additional bond, and to pharmaceutically acceptable acid addition salts thereof. The compounds are agonists and/or antagonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.
公开/授权文献
- EP0963985B1 Di-or triaza-spiro(4,5)decane derivatives 公开/授权日:2003-03-12
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