发明授权
EP0966477B1 3'-N-OXIDE, 3'-N-DIMETHYLAMINE, 9-OXIME ERYTHROMYCIN A DERIVATIVES
失效
3'-N-氧化物，3'-N-二甲基胺，9-肟红霉素A衍生物
- 专利标题： 3'-N-OXIDE, 3'-N-DIMETHYLAMINE, 9-OXIME ERYTHROMYCIN A DERIVATIVES
- 专利标题（中）： 3'-N-氧化物，3'-N-二甲基胺，9-肟红霉素A衍生物
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申请号： EP98904822.8申请日： 1998-02-03
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公开(公告)号： EP0966477B1公开(公告)日： 2003-10-15
- 发明人: KU, Yi-Yin , RILEY, David, A.
- 申请人： Abbott Laboratories
- 申请人地址： Chad 0377/AP6D-2, 100 Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： Chad 0377/AP6D-2, 100 Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 代理机构： Modiano, Guido, Dr.-Ing.
- 优先权： US800009 19970213
- 国际公布： WO98035976 19980820
- 主分类号： C07H17/08
- IPC分类号： C07H17/08 ; A61K31/70
摘要：
The disclosed invention relates to novel 3'-N-O, 9-O-oxime protected, 6-O-alkyl erythromycin derivatives of formula (I), a process of preparing the same. The invention also relates to a process of preparing 6-O-alkyl erythromycin A by eliminating the 3'-N-oxide group and 9-O-oxime protecting groups and optionally deprotecting the hydroxy groups at the 2'- and 4''- positions under suitable reaction conditions.
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