发明公开
EP0971878A1 AMINE COMPOUNDS, THEIR PRODUCTION AND USE AS AMYLOID-BETA PRODUCTION INHIBITORS
失效
阿明衍生物,生产与应用,生产β淀粉样蛋白的抑制剂
- 专利标题: AMINE COMPOUNDS, THEIR PRODUCTION AND USE AS AMYLOID-BETA PRODUCTION INHIBITORS
- 专利标题(中): 阿明衍生物,生产与应用,生产β淀粉样蛋白的抑制剂
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申请号: EP98905656.9申请日: 1998-02-26
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公开(公告)号: EP0971878A1公开(公告)日: 2000-01-19
- 发明人: KATO, Kaneyoshi , TERAUCHI, Jun , FUKUMOTO, Hiroaki , KAKIHANA, Mitsuru
- 申请人: Takeda Chemical Industries, Ltd.
- 申请人地址: 1-1 Doshomachi 4-chome,Chuo-ku Osaka-shi,Osaka 541-0045 JP
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: 1-1 Doshomachi 4-chome,Chuo-ku Osaka-shi,Osaka 541-0045 JP
- 代理机构: Hall, Marina
- 优先权: JP4394097 19970227; JP19349797 19970718
- 国际公布: WO9838156 19980903
- 主分类号: C07C217/74
- IPC分类号: C07C217/74 ; A61K31/135 ; C07C255/54 ; C07D295/08 ; C07C233/43 ; C07D211/26 ; C07C311/21 ; C07C211/60 ; C07C323/19 ; C07D333/16 ; C07D213/30 ; C07D211/44 ; C07C217/76 ; C07C233/25 ; C07D317/54
摘要:
A compound of formula (I) wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) -S-, -SO- or -SO2-, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) -CO-O- or (v) -(CH2)p-x1-, -(CH¿2?)p-X?1-(CH¿2)q-, -(CH2)r-CO-X1-, -SO¿2-NR?8- or -(CH¿2?)r-SO2-NR?8¿- wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C¿1-6? aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R?1 and R2¿ each is H or a lower alkyl which may be substituted, or R?1 and R2¿ form an N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-β protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.
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