公开(公告)号：EP3694557B1

公开(公告)日：2022-04-13

申请号：EP18867198.6

申请日：2018-10-11

Inventor： LEMIEUX, Marc ,  MITRASCA, Bradut ,  GERVAIS, Sonia ,  SMITH, Damon

IPC: A61K47/36 ,  A61K31/137 ,  A61K31/167 ,  A61K31/437 ,  A61K31/635 ,  A61K9/20 ,  C07C217/74 ,  C07C233/25 ,  C07D231/12 ,  C07D471/04

公开(公告)号：EP3003301B1

公开(公告)日：2021-02-24

申请号：EP14804229.4

申请日：2014-05-30

Inventor： ZHANG, Hui

IPC: A61K31/27 ,  C07C271/24 ,  C07C217/74 ,  C07D295/13 ,  C07D207/14 ,  A61K45/06 ,  A61P35/00

公开(公告)号：EP2531485B1

公开(公告)日：2019-04-24

申请号：EP11740324.6

申请日：2011-02-03

Applicant: The Board of Trustees of the University of Illinois ,  The University of North Carolina at Chapel Hill

Inventor： KOZIKOWSKI, Alan ,  ROTH, Bryan ,  SVENNEBRING, Andreas ,  CHEN, Gang ,  CHO, Sung, Jin

IPC: C07C217/74 ,  A61K31/138 ,  A61P3/00 ,  A61P25/00

公开(公告)号：EP3103790B1

公开(公告)日：2018-05-09

申请号：EP16179352.6

申请日：2008-03-13

Applicant: Auspex Pharmaceuticals, Inc.

Inventor： GANT, Thomas G. ,  SEPEHR, Sarshar ,  WOO, Soon Hyung

IPC: C07C217/74 ,  C07C215/64 ,  C07D265/16 ,  C07B59/00

CPC classification number: C07C211/64 ,  C07B59/00 ,  C07B2200/05 ,  C07B2200/07 ,  C07B2200/13 ,  C07C215/64 ,  C07C217/74 ,  C07C2601/14 ,  C07D265/16

Abstract: Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.

公开(公告)号：EP1978961B1

公开(公告)日：2016-03-16

申请号：EP06848050.8

申请日：2006-12-21

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  BUSH, Larry, R. ,  VARNEY, Mark ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  MA, Jianguo

IPC: C07D215/12 ,  C07C211/30 ,  C07C211/40 ,  C07C215/44 ,  C07C217/74 ,  A01N43/42 ,  A61K31/47

CPC classification number: C07C211/40 ,  C07C17/16 ,  C07C17/35 ,  C07C45/38 ,  C07C45/52 ,  C07C45/63 ,  C07C45/67 ,  C07C45/68 ,  C07C45/74 ,  C07C211/29 ,  C07C211/30 ,  C07C211/42 ,  C07C215/44 ,  C07C217/74 ,  C07C2601/14 ,  C07C2602/10 ,  C07D215/12 ,  C07C25/22 ,  C07C22/04 ,  C07C47/453 ,  C07C49/67 ,  C07C49/697 ,  C07C49/255 ,  C07C49/755 ,  C07C49/683

公开(公告)号：EP2580183A2

公开(公告)日：2013-04-17

申请号：EP11725636.2

申请日：2011-06-09

Applicant: GADOR S.A. ,  Conicet -Consejo Nac. De Investigaciones Científicas Y Técnicas

Inventor： TOMBARI, Dora, Graciela ,  MANGONE, Constanza, Pia ,  GARCIA, Maria, Beatriz ,  VECCHIOLI, Adriana ,  LABRIOLA, Rafael, Alberto ,  BURTON, Gerardo ,  RUSTOY, Eduardo, Miguel

IPC: C07C217/74 ,  C07C233/18 ,  C07C255/37

CPC classification number: C07C233/18 ,  C07C217/74 ,  C07C255/37

Abstract: A novel process for the preparation of N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, also known as agomelatine, Compound (I), from 7-methoxy-tetralone as starting material, and to a new crystalline form X of agomelatine.

公开(公告)号：EP2367782B1

公开(公告)日：2013-02-13

申请号：EP09801670.2

申请日：2009-12-22

Applicant: KRKA, D.D., Novo Mesto

Inventor： BOSE, Prosenjit ,  SIRIPALLI, Udaya Bhaskara Rao ,  KANDADAI, Appan Srinivas

IPC: C07C209/88 ,  C07C59/50 ,  C07D223/16 ,  C07C213/10 ,  C07C217/58 ,  C07C217/74

CPC classification number: C07C213/10 ,  C07B2200/07 ,  C07C59/50 ,  C07C217/58 ,  C07C217/74 ,  C07D223/16

公开(公告)号：EP1988398B1

公开(公告)日：2009-12-16

申请号：EP07075322.3

申请日：2007-05-02

Applicant: Randox Laboratories Ltd.

Inventor： Benchikh, Elouard ,  Fitzgerald, Stephen Peter ,  McConnell, Robert Ivan ,  Lowry, Andrew Philip

IPC: G01N33/94 ,  C07C217/74

CPC classification number: G01N33/9486

公开(公告)号：EP1322592B2

公开(公告)日：2009-06-17

申请号：EP01969791.1

申请日：2001-09-28

Applicant: Grünenthal GmbH

Inventor： BUSCHMANN, Helmut ,  MAUL, Corinna ,  SUNDERMANN, Bernd ,  JAGUSCH, Utz-Peter ,  HAURAND, Michael ,  CHIZH, Boris

IPC: C07C217/74 ,  C07C215/64 ,  C07C215/42 ,  A61K31/35 ,  A61P25/00

CPC classification number: C07C217/74 ,  C07C215/42 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D333/32

Abstract: The invention relates to substituted 1-aminobutan-3-ol derivatives, methods for the production thereof, pharmaceuticals containing said compounds and the use of substituted 1-aminobutan-3-ol derivatives for producing pharmaceuticals.

Abstract translation: 取代的1-氨基丁烷-3-醇化合物，其制备方法，含有它们的药物化合物，以及用于制备药物化合物的取代的1-氨基丁烷-3-醇化合物。

公开(公告)号：EP1870395A1

公开(公告)日：2007-12-26

申请号：EP06012531.7

申请日：2006-06-19

Applicant: KRKA, D.D., Novo Mesto

Inventor： Zupancic, Silvo ,  Skrabanja, Vida

IPC: C07C217/74 ,  C07C255/37

CPC classification number: C07C217/74 ,  C07C213/02 ,  C07C215/64 ,  C07C2601/14

Abstract: The present invention belongs to the field of organic chemistry and refers to a process for the preparation of O -desmethylvenlafaxine (1-[2-Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol) and its analogues. The invention also relates to a catalytic hydrogenation of cyano-group of the substituted acetonitrile.

Abstract translation: 本发明属于有机化学领域，是指制备O-甲基文拉法辛（1- [2-二甲基氨基）-1-（4-羟基苯基）乙基]环己醇）及其类似物的方法。 本发明还涉及取代乙腈的氰基的催化氢化。