发明公开
EP0972025A1 I-FLICE, A NOVEL INHIBITOR OF TUMOR NECROSIS FACTOR RECEPTOR-1 AND CD-95 INDUCED APOPTOSIS
失效
我proFLICE，肿瘤坏死因子受体1的新抑制剂和CD 95INDUZIERTEN凋亡
- 专利标题： I-FLICE, A NOVEL INHIBITOR OF TUMOR NECROSIS FACTOR RECEPTOR-1 AND CD-95 INDUCED APOPTOSIS
- 专利标题（中）： 我proFLICE，肿瘤坏死因子受体1的新抑制剂和CD 95INDUZIERTEN凋亡
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申请号： EP98903563.9申请日： 1998-01-21
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公开(公告)号： EP0972025A1公开(公告)日： 2000-01-19
- 发明人: NI, Jian , ROSEN, Craig, A. , DIXIT, Vishva, M. , GENTZ, Reiner, L. , KENNY, Joseph, J.
- 申请人： HUMAN GENOME SCIENCES, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 申请人地址： 9410 Key West Avenue Rockville, MD 20850-3338 US
- 专利权人： HUMAN GENOME SCIENCES, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人： HUMAN GENOME SCIENCES, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人地址： 9410 Key West Avenue Rockville, MD 20850-3338 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US34205 19970121; US54800 19970805
- 国际公布： WO9831801 19980723
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12N9/64 ; A61K38/48 ; G01N33/50
摘要：
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
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