发明公开
EP0972769A1 NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF
失效
NEUS AMID-DERIVATE UND MEDISINISCHE ZUSAMMENSETZUNGEN DIEE ENTHALTEN
- 专利标题： NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF
- 专利标题（中）： NEUS AMID-DERIVATE UND MEDISINISCHE ZUSAMMENSETZUNGEN DIEE ENTHALTEN
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申请号： EP98900698.6申请日： 1998-01-22
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公开(公告)号： EP0972769A1公开(公告)日： 2000-01-19
- 发明人: MARUYAMA, Tatsuya , ONDA, Kenichi , HAYAKAWA, Masahiko , TAKAHASHI, Takumi , SUZUKI, Takayuki , MATSUI, Tetsuo
- 申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
- 申请人地址： 3-11 Nihonbashi-Honcho, 2-chome Chuo-ku Tokyo 103 JP
- 专利权人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
- 当前专利权人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 3-11 Nihonbashi-Honcho, 2-chome Chuo-ku Tokyo 103 JP
- 代理机构： HOFFMANN - EITLE
- 优先权： JP1036097 19970123
- 国际公布： WO9832742 19980730
- 主分类号： C07D233/64
- IPC分类号： C07D233/64 ; C07D249/12 ; C07D257/04 ; C07D277/40 ; C07D277/30 ; A61K31/415 ; A61K31/41 ; A61K31/425
摘要：
An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle.
(The symbols in the formula have the following meanings. (wherein
A: heteroarylene;
X: bond, O, S, -NR 5 -, -NR 5 CO-, -NR 5 CONH-, -NR 5 SO 2 - or -NR 5 C(=NH)NH-;
R 1 : -H, -optionally substituted lower alkyl, -optionally substituted aryl, -optionally substituted heteroaryl or -optionally substituted cycloalkyl;
R 2a , R 2b : -H or -lower alkyl, which may be the same or different;
R 3 : -H or -lower alkyl;
R 4a , R 4b : -H or -OH, which may be the same different, or R 4a and R 4b are taken together to form =O or =N∼O-lower alkyl; and
R 5 : -H or -lower alkyl.)
(The symbols in the formula have the following meanings. (wherein
A: heteroarylene;
X: bond, O, S, -NR 5 -, -NR 5 CO-, -NR 5 CONH-, -NR 5 SO 2 - or -NR 5 C(=NH)NH-;
R 1 : -H, -optionally substituted lower alkyl, -optionally substituted aryl, -optionally substituted heteroaryl or -optionally substituted cycloalkyl;
R 2a , R 2b : -H or -lower alkyl, which may be the same or different;
R 3 : -H or -lower alkyl;
R 4a , R 4b : -H or -OH, which may be the same different, or R 4a and R 4b are taken together to form =O or =N∼O-lower alkyl; and
R 5 : -H or -lower alkyl.)
公开/授权文献
- EP0972769B1 NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF 公开/授权日：2003-04-16
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