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    NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF
    2.
    发明公开
    NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF 失效
    NEUS AMID-DERIVATE UND MEDISINISCHE ZUSAMMENSETZUNGEN DIEE ENTHALTEN

    公开(公告)号：EP0972769A1

    公开(公告)日：2000-01-19

    申请号：EP98900698.6

    申请日：1998-01-22

    申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD.

    发明人： MARUYAMA, Tatsuya ,  ONDA, Kenichi ,  HAYAKAWA, Masahiko ,  TAKAHASHI, Takumi ,  SUZUKI, Takayuki ,  MATSUI, Tetsuo

    IPC分类号： C07D233/64 ,  C07D249/12 ,  C07D257/04 ,  C07D277/40 ,  C07D277/30 ,  A61K31/415 ,  A61K31/41 ,  A61K31/425

    CPC分类号： C07D233/64 ,  C07C217/16 ,  C07C271/16 ,  C07C271/20 ,  C07D235/16 ,  C07D249/12 ,  C07D277/30 ,  C07D277/40 ,  C07D277/42 ,  C07D285/12 ,  C07D471/04

    摘要： An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle.
    (The symbols in the formula have the following meanings. (wherein

    A: heteroarylene;
    X: bond, O, S, -NR 5 -, -NR 5 CO-, -NR 5 CONH-, -NR 5 SO 2 - or -NR 5 C(=NH)NH-;
    R 1 : -H, -optionally substituted lower alkyl, -optionally substituted aryl, -optionally substituted heteroaryl or -optionally substituted cycloalkyl;
    R 2a , R 2b : -H or -lower alkyl, which may be the same or different;
    R 3 : -H or -lower alkyl;
    R 4a , R 4b : -H or -OH, which may be the same different, or R 4a and R 4b are taken together to form =O or =N∼O-lower alkyl; and
    R 5 : -H or -lower alkyl.)

    摘要翻译： 由以下通式（I）表示的酰胺衍生物或其盐和含有酰胺衍生物和药学上可接受的载体的药物组合物。 （其中A：亚杂芳基; X：键，O，S，-NR 5 - ，-NR 5 CO - ， - NR 5 CONH- ，-NR 5 SO 2 - 或-NR 5 C（= NH）NH-; R 1：-H， - 取代的低级烷基， - 取代的芳基， - 取代的杂芳基或 - 取代的环烷基 R 2a，R 2b：-H或 - 低级烷基，其可以相同或不同; R 3：-H或 - 低级烷基; R 4a，R 4b：-H 或-OH，其可以是相同的，或者R 4a和R 4b一起形成= O或= N型O-低级烷基;以及R 5：-H或 - 低级烷基。 ）

    NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF
    3.
    发明授权
    NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF 失效
    新的奎宁环衍生物和药物制剂含有它们的

    公开(公告)号：EP0801067B1

    公开(公告)日：2003-03-05

    申请号：EP95942276.7

    申请日：1995-12-27

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： TAKEUCHI, Makoto ,  NAITO, Ryo ,  HAYAKAWA, Masahiko ,  OKAMOTO, Yoshinori ,  YONETOKU, Yasuhiro ,  IKEDA, Ken ,  ISOMURA, Yasuo

    IPC分类号： C07D453/02 ,  A61K31/435

    CPC分类号： C07D221/12 ,  C07D453/02 ,  C09K19/3444

    摘要： A quinuclidine derivative represented by general formula (I), a salt, N-oxide or quaternary ammonium salt thereof, and a medicinal composition containing the same, wherein the ring A represents optionally substituted aryl, cycloalkyl, cycloalkenyl, heteroaryl containing 1 to 4 heteroatoms selected from among oxygen, nitrogen and sulfur, or 5- to 7-membered saturated heterocycle; X represents a single bond or methylene; R represents halogeno, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, lower acyl, mercapto, lower alkylthio, sulfonyl, lower alkylsulfonyl, sulfinyl, lower alkylsulfinyl, sulfonamido, lower alkanesulfonamido, carbamoyl, thio-carbamoyl, mono- or di(lower alkyl)carbamoyl, nitro, cyano, amino, mono- or di(lower alkyl)amino, methylenedioxy, ethylenedioxy or lower alkyl optionally substituted by halogeno, hydroxy, lower alkoxy, amino or mono- or di(lower alkyl)amino; 1 is 0 or 1; m is an integer of 1 to 3; and n is an integer of 1 or 2. The compound has an antagonistic effect on muscarine M3 receptors and is useful as a preventive or remedy for urologic diseases, respiratory diseases or digestive diseases.

    NOVEL CARBAMATE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME
    6.
    发明公开
    NOVEL CARBAMATE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME 失效
    碳酸钙在DIESE ENTHALTENDE ARZNEIMITTEL

    公开(公告)号：EP0747355A1

    公开(公告)日：1996-12-11

    申请号：EP95907855.1

    申请日：1995-02-08

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： TAKEUCHI, Makoto 9-14, Matsumaedai 7-chome ,  NAITO Ryo ,  MORIHIRA, Koichiro 22-5-302, Kitasenzoku 1-chome ,  HAYAKAWA, Masahiko ,  IKEDA, Ken ,  ISOMURA, Yasuo

    IPC分类号： C07D211/46 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D451/04 ,  C07D453/02 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445

    CPC分类号： C07D451/06 ,  C07D211/46 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D453/02

    摘要： Carbamate derivatives represented by the general formula (I), salts thereof, hydrates thereof or solvates thereof
    wherein each symbol has the following meaning:

    A ring: a benzene ring or a pyridine ring,
    B ring: a nitrogen-containing saturated hetero-ring which may have a substituent on the nitrogen atom and which may have a cross-linking,
    R 1 : a phenyl group which may have a substituent, a cycloalkyl or cycloalkenyl group having 3 to 8 carbon atoms or a five- or six-membered nitrogen-containing heterocyclic group,
    X: a single bond or a methylene group,
    Y: a single bond, a carbonyl group, a methylene group which may be substituted with a hydroxyl group or a group represented by the formula -S(O) ℓ -, and
    ℓ: an integer of 0, 1 or 2.

    They have muscarinic M 3 receptor antagonism and are useful as an agent for the prevention and treatment of gastrointestinal diseases, respiratory diseases or urinary diseases.

    摘要翻译： 由通式（I）表示的氨基甲酸酯衍生物，其盐，其水合物或溶剂合物其中每个符号具有以下含义：A环：苯环或吡啶环，B环：含氮饱和杂原子 其可以在氮原子上具有取代基并且可以具有交联R 1：可以具有取代基的苯基，具有3-8个碳原子的环烷基或环烯基或五或 六元含氮杂环基，X：单键或亚甲基，Y：单键，羰基，可被羟基取代的亚甲基或由式-S表示的基团（ O）1 - 和l：0,1或2的整数。它们具有毒蕈碱性M3受体拮抗作用，可用作预防和治疗胃肠道疾病，呼吸系统疾病或尿路疾病的药剂。