发明公开
- 专利标题： Human gastric cancer antigen gene and protein
- 专利标题（中）： 人类基因和蛋白的胃癌抗原的
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申请号： EP99305469.1申请日： 1999-07-09
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公开(公告)号： EP0974653A3公开(公告)日： 2001-09-19
- 发明人: Kikuchi, Kokichi , Sato, Noriyuki , Torigoe, Toshihiko , Sahara, Hiroeki , Suzuki, Manabu, c/o Ajinomoto Co., Inc. , Hamuro, Junji, c/o Ajinomoto Co., Inc.
- 申请人： Ajinomoto Co., Inc. , Kikuchi, Kokichi
- 申请人地址： No. 15-1, Kyobashi 1-chome, Chuo-ku Tokyo 104 JP
- 专利权人： Ajinomoto Co., Inc.,Kikuchi, Kokichi
- 当前专利权人： Ajinomoto Co., Inc.,Kikuchi, Kokichi
- 当前专利权人地址： No. 15-1, Kyobashi 1-chome, Chuo-ku Tokyo 104 JP
- 代理机构： Nicholls, Kathryn Margaret
- 优先权： JP19785298 19980713
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C07K14/47 ; A61K38/17 ; C07K7/06
摘要：
A tumor antigen gene is identified by screening a cDNA library derived from a gastric cancer cell line that can induce gastric cancer antigen specific cytotoxic T cell (CTL) by means of hybridization and PCR utilizing an amino acid sequence of peptide fragment of a known gastric cancer antigen protein, introducing a selected cDNA clone into a cell of gastric cancer cell line that cannot induce gastric cancer antigen specific CTL so that the clone should be expressed in the cell, and selecting a transgenic cell that has acquired the ability to induce CTL. According to the present invention, there are provided a protein capable of inducing immune response against human gastric cancer, DNA encoding the protein, as well as vaccine for treatment and prevention of human gastric cancer, and agent for treatment and prevention of human gastric cancer.
公开/授权文献
- EP0974653B1 Human gastric cancer antigen gene and protein 公开/授权日：2005-09-14
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