发明公开
- 专利标题： INHIBITORS OF CHOLESTEROL ESTERASE
- 专利标题（中）： 胆固醇酯酶抑制剂
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申请号： EP98918098.9申请日： 1998-04-15
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公开(公告)号： EP0975617A1公开(公告)日： 2000-02-02
- 发明人: DECK, Lorraine , VANDER JAGT, David, L.
- 申请人： The University of New Mexico
- 申请人地址： Hokano Hall, Zuni Wig,Room 357 Albuquerque, NM 87131 US
- 专利权人： The University of New Mexico
- 当前专利权人： The University of New Mexico
- 当前专利权人地址： Hokano Hall, Zuni Wig,Room 357 Albuquerque, NM 87131 US
- 代理机构： Klunker . Schmitt-Nilson . Hirsch
- 优先权： US41988P 19970416
- 国际公布： WO9846585 19981022
- 主分类号： C07D307/20
- IPC分类号： C07D307/20 ; C07D307/88 ; C07D309/38 ; C07D311/76 ; C07D315/00
摘要：
The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.
公开/授权文献
- EP0975617B1 INHIBITORS OF CHOLESTEROL ESTERASE 公开/授权日：2003-11-05
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