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公开(公告)号：EP1035780A1
公开(公告)日：2000-09-20
申请号：EP98961905.1
申请日：1998-12-04
CPC分类号： C07K14/4702
摘要： The present invention provides a method for synthesizing heat shock protein-peptide complexes comprising the steps of: adding a shock protein to a denatured protein matrix to bind the heat shock protein to the denatured protein matrix; and adding a complexing solution comprising a peptide to elute a heat shock protein-peptide complex. The present invention also provides a heat shock protein-peptide complex synthesized by the method of the invention. In addition the present invention provides an apparatus for synthesizing heat shock protein-peptide complexes comprising a heat shock protein complex bound to a denatured protein matrix. The present invention also provides a method for treating an allergic disease in which a heat shock protein-antigen complex is administered to a mammal in an amount sufficient to reduce the susceptibility of the mammal to a Th2 response for the allergic disease. The method of the present invention can be used either to prevent an invididual from having an allergic reaction to an allergic disease or to reduce the effects of an allergic disease in an individual already suffering from the allergic disease.
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公开(公告)号：EP0950061A1
公开(公告)日：1999-10-20
申请号：EP97945246.0
申请日：1997-09-19
发明人： WALLEN, Erik, S. , ROIGAS, Jan , MOSLEY, Pope, L.
CPC分类号： C07K14/4702 , C07K14/39 , G01N33/6872 , G02B5/305 , Y10S435/803
摘要： A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock protein complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution product. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so produced is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock protein as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in an elution product.
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公开(公告)号：EP0930918A2
公开(公告)日：1999-07-28
申请号：EP97912654.0
申请日：1997-09-09
CPC分类号： A62D1/0057
摘要： A set of blends for extinguishment of fires, suppression of explosions, and inertion against fires and explosions is disclosed. The blends are comprised of a bromine-containing component and a fluorine-containing component. The bromine-containing component is comprised of one or more hydrobromoalkanes, hydrobromoalkenes, and/or hydrobromoarenes. The fluorine-containing component is comprised of one or more fluorine-containing halocarbons, which may also contain chlorine. Specifically provided as fluorine-containing halocarbons are saturated and unsaturated hydrochlorofluorocarbons, hydrofluorocarbons, perfluorocarbons, perfluoroethers, hydrofluoroethers, and/or hydrofluoropolyethers. This provides a blend that mimics the fire and explosion protection action of halons and hydrobromofluorocarbons without the environmental impact associated with these compounds, which contain bromine and fluorine in the same molecule.
摘要翻译： 公开了一套用于扑灭火灾，抑制爆炸以及防止火灾和爆炸的混合物。 共混物由含溴组分和含氟组分组成。 含溴组分由一种或多种氢溴烷烃，氢溴烯烃和/或氢溴酸盐组成。 含氟组分由一种或多种也可能含有氯的含氟卤代烃组成。 作为含氟卤代烃特别提供饱和和不饱和氯氟代烃，氢氟代烃，全氟代烃，全氟代醚，氢氟代醚和/或氢氟代聚醚。 这提供了一种混合物，它模拟哈龙和氢溴氟烃的防火和防爆作用，而不会对这些化合物产生环境影响，这些化合物在同一分子中含有溴和氟。
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公开(公告)号：EP0656193A2
公开(公告)日：1995-06-07
申请号：EP95102423.1
申请日：1991-02-12
摘要： 1. A tool comprising:
a body (10) comprising a pair of flexible leaves (12, 14) joined at their forward ends by a bridge (16) having an elongate aperture (22) therein, said leaves also being joined face-to face at their rearward ends, and being normally bowed outward from one another; and
an elongated collet (40) having a rearward end affixed to the rearward ends of said leaves, and a bifurcated forward end comprising a pair of resiliently flexible tines (44, 46), each tine having thereon a jaw (48) protruding through said aperture, each jaw including an inwardly facing working surface (50) and an outwardly facing oblique cam surface (52) in a position to engage a side of said aperture, so that relative longitudinal movement between the bridge and the jaws, produced by squeezing the leaves together, causes interaction between the sides of the aperture and the cam surfaces to drive the jaws together
is improved by providing that:
the tines of the collet lie in a common plane perpendicular to and bisecting both of said leaves, the length of the aperture being aligned with said plane; and
the two opposed leaves and the bridge are within a blank of sheet material, the aperture being formed within the sheet.摘要翻译： 1.一种工具，包括：主体（10），包括一对柔性叶片（12,14），所述柔性叶片在其前端处由其中具有细长孔（22）的桥（16）连接，所述叶片还面向 面对其后端，并且通常彼此向外弯曲; 和一个细长的夹头（40），其具有固定到所述叶片的后端的后端，以及分叉的前端，其包括一对弹性柔性的尖齿（44,46），每个齿上具有突出穿过所述叶片 孔，每个钳口包括面向内的工作表面（50）和面向外的倾斜凸轮表面（52），其位于与所述孔的一侧接合的位置，从而通过挤压所述孔而产生桥和钳口之间的相对纵向运动 通过提供以下优点来提高孔的两侧之间的相互作用和凸轮表面之间的相互作用以将夹爪驱动在一起：夹具的尖齿位于垂直于和等分两个叶的公共平面中，孔的长度 与所述平面对齐; 并且两个相对的叶片和桥梁在片材的空白内，孔被形成在片材内。
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公开(公告)号：EP1062543A1
公开(公告)日：2000-12-27
申请号：EP99906798.6
申请日：1999-02-08
发明人： JAIN, Ravinder , SRINIVASAN, Balaji
CPC分类号： G02B6/29322 , G02B6/02195 , G02B6/022 , G02B6/274 , G02B6/2746 , G02B6/29353 , G02B6/29355 , G02B6/4207 , G02F1/011 , G02F1/0115 , G02F1/3558 , G02F2001/212 , G02F2001/215 , G02F2201/307 , G02F2202/06 , G02F2202/07 , G02F2203/055 , G02F2203/07 , G02F2203/585 , G02F2203/62 , H01S3/0675 , H01S3/105
摘要： A D type optical fiber (10') was adhered to a conductive layer (18) through the flat side of the optical fiber (10') and the cladding (16) was removed in area (20) without damage to the core (14). Electrical connection is made through the projection (24) which allows good contact when used alone or in conjunction with a previously deposited conductor (20). The cladding removal process may also be done on both sides when a round optical fiber is used rather than a D type fiber. The electrooptical devices made using this process may also include bragg gratings which may be impressed using an applied voltage, UV radiation, thermal heating or a combination of any of these.
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6.发明公开METHODS AND APPARATUS FOR INTEGRATING OPTICAL AND INTERFEROMETRIC LITHOGRAPHY TO PRODUCE COMPLEX PATTERNS 失效光学和干涉LITHOGRAPHIE为复杂图案的生产一体化
公开(公告)号：EP0960356A1
公开(公告)日：1999-12-01
申请号：EP98904595.0
申请日：1998-01-21
CPC分类号： G03F7/70125 , G03F7/2022 , G03F7/70241 , G03F7/70408 , G03F7/7045
摘要： The present invention provides methods and apparatus for defining a single structure (11) on a semiconductor wafer by spatial frequency components whereby some of the spatial frequency components (12-16) are derived by optical lithography and some by interferometric lithography techniques. Interferometric lithography images the high frequency components while optical lithography images the low frequency components. Optics collects many spatial frequencies and the interferometry shifts the spatial frequencies to high spatial frequencies. Thus, because the mask does not need to provide high spatial frequencies, the masks are configured to create only low frequency components, thereby allowing fabrication of simpler masks having larger structures. These methods and apparatus facilitate writing more complex repetitive as well as non-repetitive patterns in a single exposure with a resolution which is higher than that currently available using known optical lithography alone.
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7.发明授权Method for making silver-palladium alloy powders by areosol decomposition 失效一种用于通过气溶胶分解制备银 - 钯粉末的过程
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公开(公告)号：EP0515545B1
公开(公告)日：1995-11-08
申请号：EP91905191.2
申请日：1991-02-12
摘要： A surgical tool for cutting, shearing or clamping has a body (10) formed of a single length of flexible steel and a collet (40) mounted perpendicularly between the leaves (12, 14) of the body (10) and affixed between the leaves (12, 14) near their rearward ends. The leaves (12, 14) are normally bowed outward, so that squeezing them together lengthens the body (10), thus producing relative displacement between the forward ends of the body (10) and collet (40), respectively. The bifurcated forward end of the collet (40), which extends through an aperture (22) in a bridge (16) joining the leaves (12, 14), terminates at a pair of jaws (48) having inwardly working surfaces (50) and outwardly facing cam surfaces (52). The cams (52) are engaged by the sides (24) of the aperture (22), which drive the jaws (48) together when the leaves (12, 14) are squeezed toward one another.
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公开(公告)号：EP1323715A1
公开(公告)日：2003-07-02
申请号：EP03006153.5
申请日：1998-04-15
IPC分类号： C07D307/20 , C07D309/32 , C07D315/00
CPC分类号： C07D309/32 , C07D307/58 , C07D307/88 , C07D311/76
摘要： The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.
摘要翻译： 本发明提供了作为胆固醇酯酶的活性位点抑制剂有效的新型卤烯醇内酯。 通过抑制胆固醇酯酶，本发明的抑制剂通过限制膳食胆固醇的生物利用度提供了治疗高胆固醇血症的新方法。
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