发明公开
- 专利标题： 2,3-DISUBSTITUTED CYCLOPENTANONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF
- 专利标题（中）： 2,3-二取代环戊酮衍生物，其医疗应用过程产生和
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申请号： EP97901810.8申请日： 1997-01-31
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公开(公告)号： EP0976709A1公开(公告)日： 2000-02-02
- 发明人: SAITO, Seiichi , MORINO, Tomio , MASUDA, Kuniko
- 申请人： NIPPON KAYAKU CO., LTD.
- 申请人地址： 11-2, Fujimi 1-chome Chiyoda-ku, Tokyo 102 JP
- 专利权人： NIPPON KAYAKU CO., LTD.
- 当前专利权人： NIPPON KAYAKU CO., LTD.
- 当前专利权人地址： 11-2, Fujimi 1-chome Chiyoda-ku, Tokyo 102 JP
- 代理机构： Türk - Gille - Hrabal - Struck
- 优先权： JP3583496 19960131; JP29318496 19961016
- 国际公布： WO9728114 19970807
- 主分类号： C07C49/517
- IPC分类号： C07C49/517
摘要：
The present invention relates to a compound represented by the following general formula (1)
(wherein X represents O, S, SO, SO 2 , or NH, Y is a substituted or unsubstituted hydrocarbon residue containing 1 through 6 carbon atoms and having an overall molecular weight of not less than 15 and not more than 400, and the hydrocarbon residue, when the residue is ring, may contain one or two hetero-atoms in the ring, and Z is a carboxyl group , a group derived therefrom or an aliphatic hydrocarbon residue having from 1 to 4 carbon atoms which may be substituted or unsabstituted ) or a pharmacologically acceptable salt thereof (excluding (1R,2S)-2- [ (2R)-(2-acetylamino-2-carboxyethyl) thiomethyl ] -3-oxo-1-cyclopentanecarboxylic acid (cystacyclin)), a method for production thereof and a medicinal use thereof. The compound of the present invention is useful as a neuron differentiation accelerator.
(wherein X represents O, S, SO, SO 2 , or NH, Y is a substituted or unsubstituted hydrocarbon residue containing 1 through 6 carbon atoms and having an overall molecular weight of not less than 15 and not more than 400, and the hydrocarbon residue, when the residue is ring, may contain one or two hetero-atoms in the ring, and Z is a carboxyl group , a group derived therefrom or an aliphatic hydrocarbon residue having from 1 to 4 carbon atoms which may be substituted or unsabstituted ) or a pharmacologically acceptable salt thereof (excluding (1R,2S)-2- [ (2R)-(2-acetylamino-2-carboxyethyl) thiomethyl ] -3-oxo-1-cyclopentanecarboxylic acid (cystacyclin)), a method for production thereof and a medicinal use thereof. The compound of the present invention is useful as a neuron differentiation accelerator.
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