发明授权
EP0980368B1 DERIVES DE 3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE ET LEUR UTILISATION COMME LIGANDS 5-HT4
失效
3-（3-吡咯烷基）-2-（3H）-1,3,4- OXADIAZOLONDERIVATE及其作为5-HT 4配体
- 专利标题： DERIVES DE 3-(PYRROLIDIN-3-YL)-1,3,4-OXADIAZOL-2(3H)-ONE ET LEUR UTILISATION COMME LIGANDS 5-HT4
- 专利标题（英）： 3-(pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3h)-one derivatives and their use as 5-ht4 ligands
- 专利标题（中）： 3-（3-吡咯烷基）-2-（3H）-1,3,4- OXADIAZOLONDERIVATE及其作为5-HT 4配体
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申请号： EP98924365.4申请日： 1998-05-04
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公开(公告)号： EP0980368B1公开(公告)日： 2003-10-22
- 发明人: LOCHEAD, Alistair , JEGHAM, Samir , JEUNESSE, Jean , NEDELEC, Alain
- 申请人： SANOFI-SYNTHELABO
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： SANOFI-SYNTHELABO
- 当前专利权人： SANOFI-SYNTHELABO
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Ludwig, Jacques
- 优先权： FR9705539 19970506
- 国际公布： WO98050381 19981112
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; C07D413/14 ; A61K31/41 ; A61K31/445
摘要：
The invention concerns compounds of general formula (I) in which R1 represents hydrogen or an alkyl or cycloalkylmethyl group, X1 represents hydrogen or a halogen or an alkoxy group or OR1 and X1 together represent a group of formula -OCH2O-, -O(CH2)2-, -O(CH2)3-, -O(CH2)2O, or -O(CH2)3O-, X2 represents hydrogen, an amino group or a group of general formula -NHCO2R in which R represents an alkyl or phenylalkyl group, X3 represents hydrogen or a halogen, and R2 represents hydrogen or an alkyl, phenylalkyl or [(4-dimethylamino)piperidin-1-ylcarbonyl]alkyl group. The invention is applicable in therapy. Said compounds can be used for treating or preventing disorders in which 5-HT4 receptors are involved, whether in the central nervous, the gastrointestinal, the cardiovascular or the urinary system.
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