公开(公告)号：EP0980368B1

公开(公告)日：2003-10-22

申请号：EP98924365.4

申请日：1998-05-04

申请人： SANOFI-SYNTHELABO

发明人： LOCHEAD, Alistair ,  JEGHAM, Samir ,  JEUNESSE, Jean ,  NEDELEC, Alain

IPC分类号： C07D413/04 ,  C07D413/14 ,  A61K31/41 ,  A61K31/445

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The invention concerns compounds of general formula (I) in which R1 represents hydrogen or an alkyl or cycloalkylmethyl group, X1 represents hydrogen or a halogen or an alkoxy group or OR1 and X1 together represent a group of formula -OCH2O-, -O(CH2)2-, -O(CH2)3-, -O(CH2)2O, or -O(CH2)3O-, X2 represents hydrogen, an amino group or a group of general formula -NHCO2R in which R represents an alkyl or phenylalkyl group, X3 represents hydrogen or a halogen, and R2 represents hydrogen or an alkyl, phenylalkyl or [(4-dimethylamino)piperidin-1-ylcarbonyl]alkyl group. The invention is applicable in therapy. Said compounds can be used for treating or preventing disorders in which 5-HT4 receptors are involved, whether in the central nervous, the gastrointestinal, the cardiovascular or the urinary system.

公开(公告)号：EP1135389A1

公开(公告)日：2001-09-26

申请号：EP99973291.0

申请日：1999-12-01

申请人： SANOFI-SYNTHELABO

发明人： LOCHEAD, Alistair ,  JEGHAM, Samir ,  NEDELEC, Alain ,  GALLI, Frédéric ,  JEUNESSE, Jean ,  EVEN, Luc

IPC分类号： C07D471/08 ,  A61K31/551

CPC分类号： C07D471/08

摘要： The invention concerns compounds of general formula (I) wherein one of the symbols X, Y and Z represents a nitrogen atom, another represents a group of formula C-R3 and the third represents a nitrogen atom or a group of formula C-R4; R3 and R4 represent each, independently of each other, a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, (C1-C6)alkyl or (C1-C6) alkoxy group; R1 and R2 represent each, independently of each other, a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, or phenyl group optionally substituted. The invention is applicable in therapy.

公开(公告)号：EP1135389B1

公开(公告)日：2003-09-10

申请号：EP99973291.0

申请日：1999-12-01

申请人： SANOFI-SYNTHELABO

发明人： LOCHEAD, Alistair ,  JEGHAM, Samir ,  NEDELEC, Alain ,  GALLI, Frédéric ,  JEUNESSE, Jean ,  EVEN, Luc

IPC分类号： C07D471/08 ,  A61K31/551

CPC分类号： C07D471/08

摘要： The invention concerns compounds of general formula (I) wherein one of the symbols X, Y and Z represents a nitrogen atom, another represents a group of formula C-R3 and the third represents a nitrogen atom or a group of formula C-R4; R3 and R4 represent each, independently of each other, a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, (C1-C6)alkyl or (C1-C6) alkoxy group; R1 and R2 represent each, independently of each other, a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, or phenyl group optionally substituted. The invention is applicable in therapy.

公开(公告)号：EP1144413B1

公开(公告)日：2004-03-17

申请号：EP99973293.6

申请日：1999-12-01

申请人： SANOFI-SYNTHELABO

发明人： LOCHEAD, Alistair ,  JEGHAM, Samir ,  NEDELEC, Alain ,  JEUNESSE, Jean ,  GALLI, Frédéric ,  EVEN, Luc

IPC分类号： C07D487/08 ,  A61K31/44 ,  A61K31/501

CPC分类号： C07D487/08

摘要： The invention concerns compounds of general formula (I) wherein one of the symbols X, Y and Z represents a nitrogen atom, another represents a group of formula C-R3 and the third represents a nitrogen atom or a group of formula C-R4; R3 and R4 represent each a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, alkyl or alkoxy group; R1 and R2 represent each a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, alkyl, alkoxy or phenyl group optionally substituted or R represents a hydrogen atom or an alkyl group. The invention is applicable in therapy.

公开(公告)号：EP1144413A1

公开(公告)日：2001-10-17

申请号：EP99973293.6

申请日：1999-12-01

申请人： SANOFI-SYNTHELABO

发明人： LOCHEAD, Alistair ,  JEGHAM, Samir ,  NEDELEC, Alain ,  JEUNESSE, Jean ,  GALLI, Frédéric ,  EVEN, Luc

IPC分类号： C07D487/08 ,  A61K31/44 ,  A61K31/501

CPC分类号： C07D487/08

摘要： The invention concerns compounds of general formula (I) wherein one of the symbols X, Y and Z represents a nitrogen atom, another represents a group of formula C-R3 and the third represents a nitrogen atom or a group of formula C-R4; R3 and R4 represent each a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, alkyl or alkoxy group; R1 and R2 represent each a hydrogen or a halogen atom or a trifluoromethyl, cyano, hydroxy, alkyl, alkoxy or phenyl group optionally substituted or R represents a hydrogen atom or an alkyl group. The invention is applicable in therapy.