发明授权
EP0981644B1 AN APC MUTATION ASSOCIATED WITH FAMILIAL COLORECTAL CANCER IN ASHKENAZI JEWS
失效
在德系犹太人相关的家族性结肠癌甲APC突变GOES
- 专利标题： AN APC MUTATION ASSOCIATED WITH FAMILIAL COLORECTAL CANCER IN ASHKENAZI JEWS
- 专利标题（中）： 在德系犹太人相关的家族性结肠癌甲APC突变GOES
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申请号： EP98903558.9申请日： 1998-01-21
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公开(公告)号： EP0981644B1公开(公告)日： 2003-05-14
- 发明人: LAKEN, Steve , GRUBER, Stephen , PETERSEN, Gloria , KINZLER, Kenneth , VOGELSTEIN, Bert
- 申请人： THE JOHNS HOPKINS UNIVERSITY
- 申请人地址： 720 Rutland Avenue Baltimore, MD 21205-2109 US
- 专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： 720 Rutland Avenue Baltimore, MD 21205-2109 US
- 代理机构： Tombling, Adrian George
- 优先权： US791883 19970131
- 国际公布： WO98033940 19980806
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/574
摘要：
During routine screening of a patient with a family history of colorectal cancer for truncating APC mutations, a novel missence mutation was identified. Upon further evaluation, it was found that 6 % of Ashkenazi Jews carry this mutation, and that it was present in ∩20 % of Ashkenazis with a family history of CRC. Probes, methods, and kits for identifying individuals affected with this missense mutation are provided.
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