专利检索 ap:("THE JOHNS HOPKINS UNIVERSITY") AND inv:"LAKEN, Steve" 第 1 页

1.

发明公开
AN APC MUTATION ASSOCIATED WITH FAMILIAL COLORECTAL CANCER IN ASHKENAZI JEWS 失效
标题翻译：在德系犹太人相关的家族性结肠癌甲APC突变GOES

公开(公告)号：EP0981644A1

公开(公告)日：2000-03-01

申请号：EP98903558.9

申请日：1998-01-21

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： LAKEN, Steve , GRUBER, Stephen , PETERSEN, Gloria , KINZLER, Kenneth , VOGELSTEIN, Bert

IPC分类号： C12Q1/68 , G01N33/574

CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/156 , G01N33/57419 , Y10S435/81 , Y10S436/813

摘要： During routine screening of a patient with a family history of colorectal cancer for truncating APC mutations, a novel missence mutation was identified. Upon further evaluation, it was found that 6 % of Ashkenazi Jews carry this mutation, and that it was present in ∩20 % of Ashkenazis with a family history of CRC. Probes, methods, and kits for identifying individuals affected with this missense mutation are provided.

2.

发明授权
AN APC MUTATION ASSOCIATED WITH FAMILIAL COLORECTAL CANCER IN ASHKENAZI JEWS 失效
标题翻译：在德系犹太人相关的家族性结肠癌甲APC突变GOES

公开(公告)号：EP0981644B1

公开(公告)日：2003-05-14

申请号：EP98903558.9

申请日：1998-01-21

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： LAKEN, Steve , GRUBER, Stephen , PETERSEN, Gloria , KINZLER, Kenneth , VOGELSTEIN, Bert

IPC分类号： C12Q1/68 , G01N33/574

CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/156 , G01N33/57419 , Y10S435/81 , Y10S436/813

摘要： During routine screening of a patient with a family history of colorectal cancer for truncating APC mutations, a novel missence mutation was identified. Upon further evaluation, it was found that 6 % of Ashkenazi Jews carry this mutation, and that it was present in ∩20 % of Ashkenazis with a family history of CRC. Probes, methods, and kits for identifying individuals affected with this missense mutation are provided.