发明授权
EP0993439B1 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS
失效
4-溴OR 4-IOD苯基氨基 - BENZHYDROXAMSÄUREDERIVATE和它们作为MEK抑制剂的用途
- 专利标题： 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS
- 专利标题（中）： 4-溴OR 4-IOD苯基氨基 - BENZHYDROXAMSÄUREDERIVATE和它们作为MEK抑制剂的用途
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申请号： EP98932830.7申请日： 1998-06-24
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公开(公告)号： EP0993439B1公开(公告)日： 2004-09-29
- 发明人: BARRETT, Stephen, Douglas , BRIDGES, Alexander, James , DOHERTY, Annette, Marian , DUDLEY, David, Thomas , SALTIEL, Alan, Robert , TECLE, Haile
- 申请人： Warner-Lambert Company LLC
- 申请人地址： 201 Tabor Road Morris Plains, New Jersey 07950 US
- 专利权人： Warner-Lambert Company LLC
- 当前专利权人： Warner-Lambert Company LLC
- 当前专利权人地址： 201 Tabor Road Morris Plains, New Jersey 07950 US
- 代理机构： Mansmann, Ivo
- 优先权： US51440P 19970701
- 国际公布： WO1999001426 19990114
- 主分类号： C07C259/10
- IPC分类号： C07C259/10 ; C07D295/08 ; C07D309/12 ; A61K31/165
摘要：
Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
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