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公开(公告)号：EP1888524A1
公开(公告)日：2008-02-20
申请号：EP06744704.5
申请日：2006-04-24
发明人： BARRETT, Stephen, Douglas , FEDIJ, Victor , HU, Lain-Yen , IULA, Donna, Michele , LEFKER, Bruce, Allen , RAHEJA, Raj, Kumar , SEXTON, Karen, Elaine , VAN CAMP, Jennifer, Ann
IPC分类号： C07D207/26 , A61K31/4015 , A61P5/28
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
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2.发明授权2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS 失效2-（4-溴OR 4-IOD苯基氨基）苯甲酸衍生物及其作为MEK抑制剂的用途
公开(公告)号：EP0993437B1
公开(公告)日：2006-11-08
申请号：EP98932829.9
申请日：1998-06-24
发明人： BARRETT, Stephen, Douglas , BRIDGES, Alexander, James , CODY, Donna, Reynolds , DOHERTY, Annette, Marian , DUDLEY, David, Thomas , SALTIEL, Alan, Robert , SCHROEDER, Mel, Conrad , TECLE, Haile
IPC分类号： C07C229/58 , C07C237/30 , C07C215/68 , C07C243/38 , C07D257/04 , C07D295/12 , A61K31/195
CPC分类号： C07D213/40 , C07C215/68 , C07C229/58 , C07C237/30 , C07C237/32 , C07C237/36 , C07C243/38 , C07C311/44 , C07D257/04 , C07D295/155 , C07D295/32 , C07D333/20
摘要： Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
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公开(公告)号：EP1144394B1
公开(公告)日：2005-08-24
申请号：EP99968150.5
申请日：1999-12-21
IPC分类号： C07D263/10 , C07D257/04 , A61K31/41 , C07D249/14 , A61K31/4196 , C07D271/113 , A61K31/4245 , C07D249/12 , A61P37/02 , A61P31/18 , A61K31/421
CPC分类号： C07D291/04 , A61K45/06 , C07D231/20 , C07D231/46 , C07D249/06 , C07D249/12 , C07D249/14 , C07D257/04 , C07D263/10 , C07D271/07 , C07D275/03 , C07D285/08
摘要： 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
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4.发明授权
公开(公告)号：EP1301472B1
公开(公告)日：2014-03-26
申请号：EP01952778.7
申请日：2001-07-12
发明人： BARRETT, Stephen, Douglas , BIWERSI, Cathlin , KAUFMAN, Michael , TECLE, Haile , WARMUS, Joseph, Scott , CHEN, Michael Huai Gu
IPC分类号： C07C259/10 , C07D295/088 , A61K31/166 , A61K31/5375
CPC分类号： C07D261/02 , C07C259/10 , C07C271/16 , C07C2601/02 , C07D295/088 , C07D317/18 , C07D319/06
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5.发明授权
公开(公告)号：EP1144371B1
公开(公告)日：2005-11-09
申请号：EP99966496.4
申请日：1999-12-21
IPC分类号： C07C311/39 , A61K31/18 , A61P5/48 , A61P17/06 , A61P19/02 , A61P25/28 , A61P31/18 , A61P35/00 , A61P37/06
CPC分类号： C07C311/39 , C07C2601/02
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公开(公告)号：EP1144385B1
公开(公告)日：2005-08-17
申请号：EP99966521.9
申请日：1999-12-21
IPC分类号： C07D235/06 , C07D263/56 , C07D277/62 , C07D285/14 , C07D271/12 , C07D235/12 , C07D235/14 , C07D241/42 , C07D249/18 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/433 , A61K31/4245 , A61K31/498 , A61K31/4192 , A61P35/00
CPC分类号： C07D235/06 , C07D235/12 , C07D235/14 , C07D241/42 , C07D249/18 , C07D263/56 , C07D271/12 , C07D277/62 , C07D285/14
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7.发明授权4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS 失效4-溴OR 4-IOD苯基氨基 - BENZHYDROXAMSÄUREDERIVATE和它们作为MEK抑制剂的用途
公开(公告)号：EP0993439B1
公开(公告)日：2004-09-29
申请号：EP98932830.7
申请日：1998-06-24
发明人： BARRETT, Stephen, Douglas , BRIDGES, Alexander, James , DOHERTY, Annette, Marian , DUDLEY, David, Thomas , SALTIEL, Alan, Robert , TECLE, Haile
IPC分类号： C07C259/10 , C07D295/08 , C07D309/12 , A61K31/165
CPC分类号： C07D295/088 , C07C259/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D211/22 , C07D307/42 , C07D309/06 , C07D309/12 , C07D333/16
摘要： Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
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